Catalog No.
PHB99602
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CHRNA1 (Gly20-Leu255).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ACHRA, Acetylcholine receptor subunit alpha, CHRNA1, CHNRA
Purification
Purified by antigen affinity column.
Accession
P02708
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Causal Variants in CHRNA1 and CHRNB1 Genes for Anti-acetylcholine Receptor Antibody Positive Myasthenia Gravis: Evidence from Bayesian Fine-Mapping and Genetic Association Study., PMID:40279038
Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization., PMID:36979710
Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study., PMID:35074870
Increased serum acetylcholine receptor α1 subunit protein in anti-acetylcholine receptor antibody-positive myasthenia gravis., PMID:31855720
Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis., PMID:30696470
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance., PMID:29099279
Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications., PMID:28440223
Juvenile-onset myasthenia gravis: autoantibody status, clinical characteristics and genetic polymorphisms., PMID:28364296
Gene Polymorphisms for Both Auto-antigen and Immune-Modulating Proteins Are Associated with the Susceptibility of Autoimmune Myasthenia Gravis., PMID:27501803
Neuronal control of localized inflammation through expressed nicotinic acetylcholine receptors: a study carried out in mice., PMID:26778394
Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis., PMID:24667415
Expression of a highly antigenic and native-like folded extracellular domain of the human α1 subunit of muscle nicotinic acetylcholine receptor, suitable for use in antigen specific therapies for Myasthenia Gravis., PMID:24376846
The α1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co-expression with the γ subunit in hair cells., PMID:17961150
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus., PMID:17687331
Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man., PMID:12935778
For research use only. Not for human or drug use.
