Catalog No.
PHG12901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human KHDRBS1 (Lys111-Gly276).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
p21 Ras GTPase-activating protein-associated p62, GAP-associated tyrosine phosphoprotein p62, KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, p68, Sam68, KHDRBS1, Src-associated in mitosis 68 kDa protein
Purification
Purified by antigen affinity column.
Accession
Q07666
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Splicing machinery is impaired in rheumatoid arthritis, associated with disease activity and modulated by anti-TNF therapy., PMID:34625402
Antibody-based biosensor to detect oncogenic splicing factor Sam68 for the diagnosis of lung cancer., PMID:32648188
Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS)., PMID:29496907
Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-κB activation in ulcerative colitis., PMID:27235792
Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections., PMID:26695943
The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs., PMID:22745822
Leptin receptor activation increases Sam68 tyrosine phosphorylation and expression in human trophoblastic cells., PMID:21035519
Protein microarray assay for the screening of SH3 domain interactions., PMID:20859618
Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor., PMID:19762470
Protein arginine-methyltransferase-dependent oncogenesis., PMID:17891136
Regulation of arginine methylation in endothelial cells: role in premature senescence and apoptosis., PMID:17726370
Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2., PMID:17200140
RET oncoproteins induce tyrosine phosphorylation changes of proteins involved in RNA metabolism., PMID:16843637
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression., PMID:16179349
Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads., PMID:15843054
Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68., PMID:14647465
Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1., PMID:12529443
The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions., PMID:12370810
Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling., PMID:12112020
Review: perinucleolar structures., PMID:10806073
Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev., PMID:10371501
Guanosine triphosphatase-activating protein-associated protein, but not src-associated protein p68 in mitosis, is a part of insulin signaling complexes., PMID:9564850
Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis., PMID:9315091
Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells., PMID:8637866
The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein., PMID:8548822
For research use only. Not for human or drug use.
