Catalog No.
PHK74501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NFKBIZ (Gln454-Leu586).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
NF-kappa-B inhibitor zeta, MAIL, IkB-zeta, IL-1 inducible nuclear ankyrin-repeat protein, INAP, NFKBIZ, I-kappa-B-zeta, IKBZ, Molecule possessing ankyrin repeats induced by lipopolysaccharide, IkappaBzeta
Purification
Purified by antigen affinity column.
Accession
Q9BYH8
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA., PMID:40460118
Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank., PMID:39384777
AMPK activation modulates IL-36-induced inflammatory responses by regulating IκBζ expression in the skin., PMID:38532634
Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature., PMID:37675983
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis., PMID:36306369
Single-Cell Transcriptome Analysis of Chronic Antibody-Mediated Rejection After Renal Transplantation., PMID:35111153
IL-17 drives salivary gland dysfunction via inhibiting TRPC1-mediated calcium movement in Sjögren's syndrome., PMID:33968407
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas., PMID:33232972
IL-1α released from oral epithelial cells upon candidalysin exposure initiates an early innate epithelial response., PMID:33038250
Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations., PMID:32832675
IκBζ is a key player in the antipsoriatic effects of secukinumab., PMID:31622687
Paradoxical psoriasis induced by TNF-α blockade shows immunological features typical of the early phase of psoriasis development., PMID:31577850
NFKBIZ and CW6 in Adalimumab Response Among Psoriasis Patients: Genetic Association and Alternative Transcript Analysis., PMID:31267486
IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production., PMID:31182790
Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells., PMID:29188404
Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells., PMID:28775123
The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation., PMID:28740238
IL-17F regulates psoriasis-associated genes through IκBζ., PMID:27576147
Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles., PMID:26869285
Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas., PMID:26647218
IκBζ: A key protein in the pathogenesis of psoriasis., PMID:26615569
Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ., PMID:25124037
Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis., PMID:23436223
Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes., PMID:19523745
Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice., PMID:18441309
Induction of the nuclear IkappaB protein IkappaB-zeta upon stimulation of B cell antigen receptor., PMID:17367755
Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein., PMID:15618216
Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease., PMID:15491998
Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4., PMID:12069074
Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs., PMID:11278262
For research use only. Not for human or drug use.
