Catalog No.
PHJ66901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HELLS (Asp523-His748).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PASG, Lymphoid-specific helicase, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, SMARCA6, HELLS, Proliferation-associated SNF2-like protein
Purification
Purified by antigen affinity column.
Accession
Q9NRZ9
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Outcomes of Selective Removals for Control of Pneumonia in a Bighorn Sheep Metapopulation., PMID:40370342
Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity., PMID:38799442
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24., PMID:37990035
Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells., PMID:37709749
Characterization of a mouse model of ICF syndrome reveals enhanced CD19 activation in inducing hypogammaglobulinemia., PMID:36945532
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination., PMID:32727902
Clinical, Immunologic and Molecular Spectrum of Patients with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome: A Systematic Review., PMID:32533820
Structural basis of specific DNA binding by the transcription factor ZBTB24., PMID:31226215
Three Types of Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome Identified by Whole-Exome Sequencing in Saudi Hypogammaglobulinemia Patients: Clinical, Molecular, and Cytogenetic Features., PMID:30511102
Expanding the mutation spectrum in ICF syndrome: Evidence for a gender bias in ICF2., PMID:28128455
Microorganisms associated with a pneumonic epizootic in Rocky Mountain bighorn sheep (Ovis canadensis canadensis)., PMID:18229860
Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin., PMID:14612388
Characterization of Pasteurella multocida associated with pneumonia in bighorn sheep., PMID:14567214
Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes., PMID:10781083
For research use only. Not for human or drug use.
