Catalog No.
PHF82202
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CDK5 (Met1-Pro292).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Cell division protein kinase 5, Cyclin-dependent-like kinase 5, TPKII catalytic subunit, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDK5, CDKN5
Purification
Purified by antigen affinity column.
Accession
Q00535
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth., PMID:38937422
Self-Assembled PD-L1 Downregulator to Boost Photodynamic Activated Tumor Immunotherapy Through CDK5 Inhibition., PMID:38856024
CRISPR-based gene expression platform for precise regulation of bladder cancer., PMID:38724931
Antibody-free time-resolved terbium luminescence assays designed for cyclin-dependent kinase 5 (CDK5)., PMID:38712268
Targeting Abnormal Tau Phosphorylation for Alzheimer's Therapeutics., PMID:38350636
Shortwave radiation-induced reproductive organ damage in male rats by enhanced expression of molecules associated with the calpain/Cdk5 pathway and oxidative stress., PMID:38155529
CDK5 destabilizes PD-L1 via chaperon-mediated autophagy to control cancer immune surveillance in hepatocellular carcinoma., PMID:38007240
Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma., PMID:37398342
VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration., PMID:37280283
Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway., PMID:36853429
In vivo analysis of the phosphorylation of tau and the tau protein kinases Cdk5-p35 and GSK3β by using Phos-tag SDS-PAGE., PMID:35430389
Relationship between plasma cyclin-dependent kinase 5 levels and local immunoglobulin levels in patients with nasal polyps., PMID:34933723
Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution., PMID:34848712
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma., PMID:34130052
Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK., PMID:33798451
Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270., PMID:33796945
AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation., PMID:33291667
Lnc-ATG9B-4 aggravates progress of hepatocellular carcinoma through cell proliferation and migration by upregulating CDK5., PMID:33023330
Experimental evidence for alpha enolase as one potential autoantigen in the pathogenesis of both autoimmune thyroiditis and its related encephalopathy., PMID:32442899
CDK5 Activates Hippo Signaling to Confer Resistance to Radiation Therapy Via Upregulating TAZ in Lung Cancer., PMID:32407930
Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner., PMID:32349283
Cdk5 Inhibitory Peptide Prevents Loss of Neurons and Alleviates Behavioral Changes in p25 Transgenic Mice., PMID:32144987
Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity., PMID:32082979
Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells., PMID:31995153
Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy., PMID:30266108
The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism., PMID:30118657
Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases., PMID:30049443
β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals., PMID:30016458
Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy., PMID:29467609
Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion., PMID:29325547
Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ., PMID:29056962
Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease., PMID:29027727
Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species., PMID:28981754
TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats., PMID:27998781
Experimental approaches for investigation of aminoacyl tRNA synthetase phosphorylation., PMID:27729295
Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins., PMID:27486244
Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis., PMID:27479491
Sunitinib activates Axl signaling in renal cell cancer., PMID:26815723
Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis., PMID:26555036
NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas., PMID:26340530
Aberrant expression of CDK5 infers poor outcomes for nasopharyngeal carcinoma patients., PMID:26339373
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing., PMID:25864429
Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neurons., PMID:25678460
Proteomic analysis of cerebrospinal fluid in Alzheimer's disease: wanted dead or alive., PMID:25428253
Clinical study of the novel cyclin-dependent kinase inhibitor dinaciclib in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia patients., PMID:25217392
Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex., PMID:25189171
Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice., PMID:25150199
Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity., PMID:24917152
Regulation of Sox6 by cyclin dependent kinase 5 in brain., PMID:24662752
CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration., PMID:24548080
For research use only. Not for human or drug use.
