Catalog No.
PHF46001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human STXBP1 (Met1-Ser594).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:200, WB: 1:500-1:4000
Target
Syntaxin-binding protein 1, Unc18-1, UNC18A, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, STXBP1, p67, Protein unc-18 homolog A, Unc-18A
Concentration
0.85 mg/ml
Purification
Purified by antigen affinity column.
Accession
P61764
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F., PMID:38484778
Genotype and phenotype spectrum of 10 children with STXBP1 gene-related encephalopathy and epilepsy., PMID:36440324
Loss of MUNC18-1 leads to retrograde transport defects in neurons., PMID:33259669
Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells., PMID:32198214
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome., PMID:26216965
Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation., PMID:23487749
Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation., PMID:23484036
Native presynaptic metabotropic glutamate receptor 4 (mGluR4) interacts with exocytosis proteins in rat cerebellum., PMID:22528491
Nuclear localization of Munc18-1 (p67) in the adult rat brain and PC12 cells., PMID:15869823
Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis., PMID:15175344
A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization., PMID:15102922
Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins., PMID:12963086
Physiological regulation of Munc18/nSec1 phosphorylation on serine-313., PMID:12950453
Munc18-syntaxin complexes and exocytosis in human platelets., PMID:12649283
Expression of p67 (Munc-18) in adult human brain and neuroectodermal tumors of human central nervous system., PMID:10672327
Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains., PMID:10620662
Munc-18-1 and cysteine string protein (csp) in pinealocytes of the gerbil pineal gland., PMID:9662647
Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4., PMID:9045631
A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants., PMID:8824310
A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin., PMID:8134339
For research use only. Not for human or drug use.
