Catalog No.
PHK71001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ARHGEF1 (Ser39-Gly230).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
p115-RhoGEF, p115RhoGEF, 115 kDa guanine nucleotide exchange factor, Sub1.5, Rho guanine nucleotide exchange factor 1, ARHGEF1
Purification
Purified by antigen affinity column.
Accession
Q92888
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Identification of Giant Isoforms of Obscurin in Rat Striated Muscles Using Polyclonal Antibodies., PMID:39441441
SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages., PMID:38135024
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function., PMID:38049580
Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population., PMID:37092056
Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells., PMID:36497137
CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition., PMID:36379207
Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes., PMID:36111670
A commercial ARHGEF17/TEM4 antibody cross-reacts with Nuclear Mitotic Apparatus protein 1 (NuMA)., PMID:35776709
Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics., PMID:34582006
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation., PMID:34471108
CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation., PMID:33879857
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias., PMID:33753942
BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation., PMID:33534893
Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development., PMID:33492483
Vav family proteins constitute disparate branching points for distinct BCR signaling pathways., PMID:32671844
Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors., PMID:32659728
Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10., PMID:32112301
B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota., PMID:31433298
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections., PMID:31433296
Inhibition of allogeneic islet graft rejection by VISTA-conjugated liposome., PMID:31272717
NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity., PMID:31235500
Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia., PMID:31230372
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells., PMID:31197029
Overexpression of PODXL/ITGB1 and BCL7B/ITGB1 accurately predicts unfavorable prognosis compared to the TNM staging system in postoperative pancreatic cancer patients., PMID:31166991
Congenital Defects in Actin Dynamics of Germinal Center B Cells., PMID:30894852
Lyn is involved in host defense against S. agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus)., PMID:30822451
ARHGEF1 deficiency reveals Gα13-associated GPCRs are critical regulators of human lymphocyte function., PMID:30714991
Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells., PMID:30568170
Loss of ARHGEF1 causes a human primary antibody deficiency., PMID:30521495
A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire., PMID:30410484
Profiling the origin, dynamics, and function of traction force in B cell activation., PMID:30087179
Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils., PMID:29601110
Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma., PMID:29549872
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation., PMID:29514960
RETRACTED: Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K., PMID:29501569
Intravital Imaging of B Cell Responses in Lymph Nodes., PMID:29476489
The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients., PMID:29235178
Mycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signalling pathway., PMID:29125705
Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity., PMID:28973398
A Novel Vav3 Homolog Identified in Lamprey, Lampetra japonica, with Roles in Lipopolysaccharide-Mediated Immune Response., PMID:28937614
Advantages of targeting B cell receptor complex to treat B-cell derived autoimmune diseases and lymphomas., PMID:28644972
MYC protein dysregulation is driven by BCR-PI3K signalling in diffuse large B-cell lymphoma., PMID:28639315
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume., PMID:28542600
Targeting ROR1 identifies new treatment strategies in hematological cancers., PMID:28408486
Proteomic Characteristics of Blood Serum in Rats with Different Behavioral Parameters after Acute Stress., PMID:28361418
Expression Profiles Analysis and Functional Characterization of MicroRNA-660 in Skeletal Muscle Differentiation., PMID:28106300
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis., PMID:28053322
Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection., PMID:27989621
Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway., PMID:27930920
For research use only. Not for human or drug use.
