Catalog No.
PHD09101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RAC2 (Met1-Leu192).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Small G protein, GX, p21-Rac2, Ras-related C3 botulinum toxin substrate 2, RAC2
Purification
Purified by antigen affinity column.
Accession
P15153
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CD300ld promotes neutrophil bacterial phagocytosis in sepsis., PMID:40376837
Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses., PMID:40369957
CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation., PMID:39990418
The association between NADPH oxidase (NOX) polymorphisms with immunohistochemistry and survival in diffuse large B cell lymphoma patients., PMID:39774928
The bone marrow endothelial progenitor cell response to septic infection., PMID:38665923
Phenotypic spectrum in a family with a novel RAC2 p.I21S dominant-activating mutation., PMID:38410820
Clinical and functional spectrum of RAC2-related immunodeficiency., PMID:38194689
Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling., PMID:37735104
Development and characterization of phage display-derived anti-toxin antibodies neutralizing TcdA and TcdB of Clostridioides difficile., PMID:37668373
Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils., PMID:37017007
Novel Loss of Function (G15D) Mutation on RAC2 in a Family with Combined Immunodeficiency and Increased Levels of Immunoglobulin G, A, and E., PMID:36459342
Combined Immunodeficiency Caused by a Novel De Novo Gain-of-Function RAC2 Mutation., PMID:35596857
Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin., PMID:35317169
A prospective study revealing the role of an immune-related eRNA, WAKMAR2, in breast cancer., PMID:34321580
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2., PMID:33570628
Effect of Grilled Nux Vomica on Differential RNA Expression Profile of Gastrocnemius Muscle and Toll‑Like Receptor 4 (TLR-4)/Nuclear Factor kappa B (NF-κB) Signaling in Experimental Autoimmune Myasthenia Gravis Rats., PMID:32052794
Phosphorylation of gp91phox/NOX2 in Human Neutrophils., PMID:31172483
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration., PMID:31143189
Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections., PMID:31071452
Methods to Study the Role of Cdc42, Rac1, and Rac2 in B-Cell Cytoskeletal Responses., PMID:30062416
Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia., PMID:29678828
The Small Rho GTPases Rac1 and Rac2 Are Important for T-Cell Independent Antigen Responses and for Suppressing Switching to IgG2b in Mice., PMID:29056938
Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration., PMID:27694496
The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein., PMID:27542411
Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108
Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID., PMID:27196803
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma., PMID:25823784
Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment., PMID:25201034
Requirement for both receptor-operated and store-operated calcium entry in N-formyl-methionine-leucine-phenylalanine-induced neutrophil polarization., PMID:23219814
The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells., PMID:23119107
Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN., PMID:22427969
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils., PMID:22366891
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages., PMID:22330068
Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway., PMID:22188208
Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis., PMID:22081935
Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue., PMID:22014524
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b., PMID:21233409
The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells., PMID:21151158
An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils., PMID:20858461
A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival., PMID:20308364
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB., PMID:19858206
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury., PMID:19801448
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells., PMID:19328020
Shwachman-Diamond syndrome neutrophils have altered chemoattractant-induced F-actin polymerization and polarization characteristics., PMID:19211642
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation., PMID:18191593
The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils., PMID:17868382
Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion., PMID:17269730
Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells., PMID:17227793
Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin., PMID:16917498
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins., PMID:16365460
For research use only. Not for human or drug use.
