Catalog No.
PHA55301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CLOCK (Ser106-Gly390).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
hCLOCK, bHLHe8, Class E basic helix-loop-helix protein 8, BHLHE8, Circadian locomoter output cycles protein kaput, CLOCK, KIAA0334
Purification
Purified by antigen affinity column.
Accession
O15516
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
The clock component LHY1b negatively regulates alkaline stress by repressing AOX1-mediated oxidative responses in soybean., PMID:40513111
Light Influences Time-of-Day Differences in the Expression of Clock Genes and Redox Genes Involved in Glutathione Homeostasis in the Lens., PMID:40478559
Genetic determinants of proteomic aging., PMID:40287427
Full-Length Cryptochrome 1 in the Outer Segments of the Retinal Blue Cone Photoreceptors in Humans and Great Apes Suggests a Role Beyond Transcriptional Repression., PMID:40277221
Emergence of a Novel Dengue Virus Serotype-2 Genotype IV Lineage III Strain and Displacement of Dengue Virus Serotype-1 in Central India (2019-2023)., PMID:40006899
Disruption of thyroid-intrinsic clock aggravates experimental autoimmune thyroiditis., PMID:39998446
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis., PMID:39819503
Chronological Effects of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer., PMID:39777632
Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination., PMID:39771992
Prokineticin 2 protein is diurnally expressed in PER2-containing clock neurons in the mouse suprachiasmatic nucleus., PMID:39755259
Period circadian clock 3 is crucial for regulation of IL-22-producing type 3 innate lymphoid cells by flavonoids from Shen Ling Bai Zhu San to alleviate colitis., PMID:39672410
The circadian clock gene BMAL1 modulates autoimmunity features in lupus., PMID:39664388
Association of the time of day of chemoradiotherapy and durvalumab with tumor control in lung cancer., PMID:39626792
BiP Proteins from Symbiodiniaceae: A "Shocking" Story., PMID:39597516
Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL)., PMID:39405013
Accelerated Phenotypic Aging Associated With Hepatitis C Infection: Results From the U.S. National Health and Nutrition Examination Surveys 2015-2018., PMID:39297494
Preclinical Evaluation of STI-8811, a Novel Antibody-Drug Conjugate Targeting BCMA for the Treatment of Multiple Myeloma., PMID:39292169
Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation., PMID:39064706
Glycan clock of ageing-analytical precision and time-dependent inter- and i-individual variability., PMID:38877341
Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity., PMID:38872947
Intravitreal Infliximab for the Treatment of Proliferative Vitreoretinopathy (FIXER): A Randomized Controlled Phase II Trial., PMID:38823559
Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms., PMID:38773499
The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression., PMID:38718296
The Benjamin Button effect on stem cells: Reversing the clock on aging immunity., PMID:38701191
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions., PMID:38509675
Seroprevalence of contagious bovine pleuropneumonia (CBPP) in cattle from Karamoja region, North-eastern Uganda., PMID:38461244
The Trissin/TrissinR signaling pathway in the circadian network regulates evening activity in Drosophila melanogaster under constant dark conditions., PMID:38430699
Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset., PMID:38400792
The rhythms of histones in regeneration: The epigenetic modifications determined by clock genes., PMID:38284199
Mapping of the gene network that regulates glycan clock of ageing., PMID:38149987
Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression., PMID:38035406
Deficiency of BMAL1 promotes ROS generation and enhances IgE-dependent degranulation in mast cells., PMID:38000295
Reversal of biological age in multiple rat organs by young porcine plasma fraction., PMID:37875652
Comparability of input parameters in the German Retina.net ROP registry and the EU-ROP registry - An exemplary comparison between 2011 and 2021., PMID:37725047
Circadian clock disruption in autoimmune thyroiditis., PMID:37548297
Pigment-dispersing factor is present in circadian clock neurons of pea aphids and may mediate photoperiodic signalling to insulin-producing cells., PMID:37369351
Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults., PMID:37334589
The countdown to type 1 diabetes: when, how and why does the clock start?, PMID:37231274
Myeloid Bmal1 deletion suppresses the house dust mite-induced chronic lung allergy., PMID:37170891
Cost-Effectiveness Analysis of Rituximab for Chronic Lymphocytic Leukemia Using a Semi-Markovian Model Approach in R., PMID:36966699
Structural properties and binding mechanism of DNA aptamers sensing saliva melatonin for diagnosis and monitoring of circadian clock and sleep disorders., PMID:36925277
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition., PMID:36747104
Superior and Anterior Glenoid Labral Tears Are Associated With Increased Neurofilament Concentration., PMID:36637166
Acute hypoxia induced dysregulation of clock-controlled ovary functions., PMID:36620217
Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity: A Multicenter Study., PMID:36396121
In Silico Genome Analysis Reveals the Evolution and Potential Impact of SARS-CoV-2 Omicron Structural Changes on Host Immune Evasion and Antiviral Therapeutics., PMID:36366559
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndrome., PMID:36241659
Evidence for overwintering and autochthonous transmission of Usutu virus to wild birds following its redetection in the United Kingdom., PMID:36217722
Time of Day of Vaccination Does Not Associate With SARS-CoV-2 Antibody Titer Following First Dose of mRNA COVID-19 Vaccine., PMID:36154515
Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism., PMID:36054336
For research use only. Not for human or drug use.
