Anti-Human MZB1 Polyclonal Antibody

Catalog No.

PHK68501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MZB1 (Asp36-Gly172).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Mesenteric estrogen-dependent adipose 7, Marginal zone B- and B1-cell-specific protein, Plasma cell-induced resident ER protein, PACAP, MZB1, Proapoptotic caspase adapter protein, Plasma cell-induced resident endoplasmic reticulum protein, pERp1, MEDA-7, MEDA7

Purification

Purified by antigen affinity column.

Accession

Q8WU39

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Machine Learning Analysis of Whole-Blood Transcriptomics Data in Rheumatoid Arthritis Patients Treated with Adalimumab Identifies Predictive Biomarkers of Response., PMID:40415615

Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)., PMID:39197587

Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine., PMID:38400120

Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis., PMID:38304234

MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation., PMID:38101774

Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA., PMID:38094295

MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps., PMID:37852603

Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo., PMID:37691146

Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis., PMID:37332260

An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:37105956

The human bone marrow plasma cell compartment in rheumatoid arthritis - Clonal relationships and anti-citrulline autoantibody producing cells., PMID:37001434

An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:36747663

Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation., PMID:36134664

Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies., PMID:35605261

Histomorphological patterns of regional lymph nodes in COVID-19 lungs., PMID:33950285

Role of Polymeric Immunoglobulin Receptor in IgA and IgM Transcytosis., PMID:33668983

A proteomic approach towards understanding the pathogenesis of Mooren's ulcer., PMID:33647271

[Histomorphological patterns of regional lymph nodes in COVID-19 lungs]., PMID:33575887

Single-cell RNA sequencing reveals cellular and molecular immune profile in a Pembrolizumab-responsive PD-L1-negative lung cancer patient., PMID:33506299

High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum., PMID:33453188

MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells., PMID:33318509

MZB1 folding and unfolding the role of IgA., PMID:31201222

MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation., PMID:31127044

Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes., PMID:30622539

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function., PMID:30257949

Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes., PMID:29382365

Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis., PMID:28654764

MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress., PMID:24888588

Missing links in antibody assembly control., PMID:24489546

High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature., PMID:23189934

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells., PMID:21093319

Document Download

Anti-Human MZB1 Polyclonal Antibody.pdf