Anti-Human KIF2C Polyclonal Antibody

Catalog No.

PHK66401

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human KIF2C (Asn229-Ser589).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Mitotic centromere-associated kinesin, Kinesin-like protein 6, KIF2C, Kinesin-like protein KIF2C, KNSL6, MCAK

Purification

Purified by antigen affinity column.

Accession

Q99661

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis., PMID:24931513

Control of MCAK degradation and removal from centromeres., PMID:22422706

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis., PMID:20705812

MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes., PMID:20406800

Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1., PMID:20368358

NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer., PMID:19937794

Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells., PMID:19931454

Kinetochore microtubule dynamics and attachment stability are regulated by Hec1., PMID:17129782

Deciphering protein function during mitosis in PtK cells using RNAi., PMID:16796742

The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK., PMID:15302853

Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity., PMID:14972678

Aurora B regulates MCAK at the mitotic centromere., PMID:14960279

Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres., PMID:9499420

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Anti-Human KIF2C Polyclonal Antibody.pdf