Catalog No.
PHA20101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human BHLHE40 (Ser46-Gly186).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
DEC1, bHLHe40, Differentially expressed in chondrocytes protein 1, Class E basic helix-loop-helix protein 40, Class B basic helix-loop-helix protein 2, STRA13, SHARP2, SHARP-2, bHLHb2, Enhancer-of-split and hairy-related protein 2, BHLHB2, BHLHE40, Stimulated by retinoic acid gene 13 protein
Purification
Purified by antigen affinity column.
Accession
O14503
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes., PMID:37751304
BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy., PMID:35181783
Bhlhe40: Gatekeeper of the GC., PMID:34940789
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis., PMID:34919144
BHLHE40 plays a pathological role in pre-eclampsia through upregulating SNX16 by transcriptional inhibition of miR-196a-5p., PMID:32579212
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer., PMID:32302573
iPSC-Derived Embryoid Bodies as Models of c-Met-Mutated Hereditary Papillary Renal Cell Carcinoma., PMID:31575031
DEC1/STRA13 is a key negative regulator of activation-induced proliferation of human B cells highly expressed in anergic cells., PMID:29601939
The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis., PMID:29277702
Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells., PMID:28250425
Global gene regulation during activation of immunoglobulin class switching in human B cells., PMID:27897229
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF., PMID:21949374
Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO., PMID:16648472
STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker., PMID:15994878
Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice., PMID:15114665
DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer., PMID:12754744
Clast5/Stra13 is a negative regulator of B lymphocyte activation., PMID:11890681
Defective T cell activation and autoimmune disorder in Stra13-deficient mice., PMID:11668339
For research use only. Not for human or drug use.
