Anti-Human ASIC1 Polyclonal Antibody

Catalog No.

PHF65201

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ASIC1 (His72-Tyr426).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

ASIC1, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, ACCN2, Acid-sensing ion channel 1, BNAC2

Purification

Purified by antigen affinity column.

Accession

P78348

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Upregulation of Acid-Sensing Ion Channel 1a in the Anterior Cingulate Cortex by TNF-α/NF-κB Pathway Contributes to Diabetes-Related Pain., PMID:40131336

Structure and analysis of nanobody binding to the human ASIC1a ion channel., PMID:34319232

Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months., PMID:33057592

Differential Expression of Acid - Sensing Ion Channels in Mouse Primary Afferents in Naïve and Injured Conditions., PMID:32508593

Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death., PMID:30042215

Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes., PMID:29595330

Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC., PMID:26394093

Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes., PMID:26359543

Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels., PMID:26032502

Acid-sensing ion channel 1 and nitric oxide synthase are in adjacent layers in the wall of rat and human cerebral arteries., PMID:25462386

Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss., PMID:24898589

Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins., PMID:20836083

Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels., PMID:20371317

Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue., PMID:19812697

ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry., PMID:19482897

Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system., PMID:12509480

Rabbit retinal neurons and glia express a variety of ENaC/DEG subunits., PMID:12055080

Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system., PMID:11842212

Increased acid-sensing ion channel ASIC-3 in inflamed human intestine., PMID:11507351

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