Catalog No.
PHF94401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ID3 (Lys2-Glu86).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ID3, 1R21, BHLHB25, bHLHb25, Class B basic helix-loop-helix protein 25, Inhibitor of differentiation 3, DNA-binding protein inhibitor ID-3, Inhibitor of DNA binding 3, HEIR1, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21
Purification
Purified by antigen affinity column.
Accession
Q02535
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion., PMID:40208940
Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients., PMID:39868279
Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)., PMID:39197587
Pre-treatment of canine plasma with heat, rather than acid, efficiently enhances Dirofilaria immitis antigen detection., PMID:38115152
CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells., PMID:37161048
The Therapeutic Mechanism of Schisandrol A and Its Metabolites on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Analysis., PMID:36814892
Losing CD45 and various B-cell markers in a case of MYC-driven pediatric high-grade B-cell lymphoma, not otherwise specified that transformed from Burkitt's lymphoma during rituximab-containing treatments: a case report., PMID:36383247
B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection., PMID:35209718
Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients., PMID:35154905
Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia., PMID:34809449
Point Mutation Specific Antibodies in B-Cell and T-Cell Lymphomas and Leukemias: Targeting IDH2, KRAS, BRAF and Other Biomarkers RHOA, IRF8, MYD88, ID3, NRAS, SF3B1 and EZH2., PMID:33801781
Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine., PMID:33562631
Micellar Casein and Whey Powder Hold a TGF-β Activity and Regulate ID Genes In Vitro., PMID:33477984
Correlation of the levels of DNA-binding inhibitor Id3 and regulatory T cells with SLE disease severity., PMID:32536579
Burkitt lymphoma: bridging the gap between advances in molecular biology and therapy., PMID:32255708
Deficient Regulatory Innate Lymphoid Cells and Differential Expression of miRNAs in Acute Myeloid Leukemia Quantified by Next Generation Sequence., PMID:32099460
Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody., PMID:32059783
[New molecular pathological strategies for malignant iris tumors]., PMID:30623224
Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis., PMID:29130990
ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells., PMID:28990057
Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells., PMID:28970806
Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL., PMID:28245840
Id3 Orchestrates Germinal Center B Cell Development., PMID:27457619
Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development., PMID:27217539
High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia., PMID:27044543
Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma., PMID:26992947
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance., PMID:26868208
Targeting vasculogenesis to prevent progression in multiple myeloma., PMID:26859080
The presence of genomic imbalances is associated with poor outcome in patients with burkitt lymphoma treated with dose-intensive chemotherapy including rituximab., PMID:26567765
Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome., PMID:26382297
B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis., PMID:26082558
IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential., PMID:24498025
The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas., PMID:24493312
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development., PMID:24463518
Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development., PMID:24244015
Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation., PMID:24115031
Tumor stress-induced phosphoprotein1 (STIP1) as a prognostic biomarker in ovarian cancer., PMID:23468915
Expression pattern of id proteins in medulloblastoma., PMID:23397264
Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy., PMID:23311395
Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain., PMID:22910287
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics., PMID:22885699
Contribution of IL-13 to early exocrinopathy in Id3-/- mice., PMID:21924496
Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease., PMID:21801865
Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium., PMID:21454537
[Preparation of rabbit antibody against human Id3 and identification of intracellular localization of Id3 in tumor cells]., PMID:20815983
Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus., PMID:20359360
[Gene expression of OAZ pathway in the patients of systemic lupus erythematosus]., PMID:20017333
[Relationship between the effect of vascular endothelial growth factor on epithelial-mesenchymal transition of HK-2 cells and the expressions of bone morphogenetic protein-7 and inhibitor of DNA binding/differentiation]., PMID:19180920
Is Inhibitor of differentiation 3 involved in human primary Sjögren's syndrome?, PMID:18296721
B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice., PMID:17472721
For research use only. Not for human or drug use.
