Anti-Human NPC2 Polyclonal Antibody

Catalog No.

PHF46401

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NPC2 (Asp31-Leu151).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HE1, NPC intracellular cholesterol transporter 2, He1, Epididymal secretory protein E1, Human epididymis-specific protein 1, NPC2, Niemann-Pick disease type C2 protein

Purification

Purified by antigen affinity column.

Accession

P61916

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

A microarray-based IgE-molecular mimicry index (IgE-MMI): A biomarker for disease severity, clinical phenotypes, and therapeutic response in atopic dermatitis?, PMID:39495073

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus., PMID:38526940

Role of Small Molecule Ligands in IgE-Mediated Allergy., PMID:37351723

USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1., PMID:34965422

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity., PMID:34721393

Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2-Allergy Explorer., PMID:34067936

Primary cilium alterations and expression changes of Patched1 proteins in niemann-pick type C disease., PMID:28332184

The NPC2 protein: A novel dog allergen., PMID:26995145

Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice., PMID:25948832

Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O., PMID:24775609

Characterization of Niemann-Pick Type C2 protein expression in multiple cancers using a novel NPC2 monoclonal antibody., PMID:24147030

Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo., PMID:20007703

Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice., PMID:19893049

NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members., PMID:15809326

Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein., PMID:15542393

Neuronal localization and association of Niemann Pick C2 protein (HE1/NPC2) with the postsynaptic density., PMID:15381285

Deficient ferritin immunoreactivity in tissues from niemann-pick type C patients: extension of findings to fetal tissues, H and L ferritin isoforms, but also one case of the rare Niemann-Pick C2 complementation group., PMID:10924274

Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1., PMID:10863096

Molecular cloning and characterization of EPI-1, the major protein in chimpanzee (Pan troglodytes) cauda epididymal fluid., PMID:8924506

Molecular cloning and characterization of HE1, a major secretory protein of the human epididymis., PMID:8924505

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