Catalog No.
PHK59301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SUFU (Gly33-Asn265).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SUFU, Suppressor of fused homolog, SUFUH
Purification
Purified by antigen affinity column.
Accession
Q9UMX1
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment., PMID:33777671
Effective anti-programmed death-1 therapy in a SUFU-mutated patient with Gorlin-Goltz syndrome., PMID:29603722
Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse., PMID:29487109
Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype., PMID:28915250
May Sonic Hedgehog proteins be markers for malignancy in uterine smooth muscle tumors?, PMID:26997437
Sonic hedgehog is a chemotactic neural crest cell guide that is perturbed by ethanol exposure., PMID:26979762
Preparation and characterization of an immunoaffinity column for the selective extraction of aflatoxin B1 in 13 kinds of foodstuffs., PMID:26160471
Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein., PMID:24422672
Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli., PMID:23551431
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling., PMID:23166838
Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu., PMID:21795282
Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium., PMID:19432668
Hedgehog signaling pathway and gastric cancer., PMID:16258256
Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis., PMID:14622141
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus., PMID:10952898
Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1., PMID:10531011
For research use only. Not for human or drug use.
