Catalog No.
PHE45601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CBX5 (Gly2-Lys80).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Heterochromatin protein 1 homolog alpha, Chromobox protein homolog 5, HP1A, Antigen p25, HP1 alpha, CBX5
Purification
Purified by antigen affinity column.
Accession
P45973
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
In vitro expression of precore proteins of hepatitis B virus subgenotype A1 is affected by HBcAg, and can affect HBsAg secretion., PMID:33854155
A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: Lipidation and polyelectrolyte complexes., PMID:33120079
Blood or skin: what is best in predicting cow's milk allergy diagnosis?, PMID:31789491
A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies., PMID:31681301
A Multi-Stage Plasmodium vivax Malaria Vaccine Candidate Able to Induce Long-Lived Antibody Responses Against Blood Stage Parasites and Robust Transmission-Blocking Activity., PMID:31119106
Accuracy of the median channel shift in the flow cytometry for predicting complement dependent cytotoxicity crossmatching in kidney transplant candidates., PMID:30367965
Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction., PMID:29464021
Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions., PMID:28234478
Study of the clinical relevance of Helicobacter pylori virulence genes to gastric diseases among Egyptian patients., PMID:27344093
Transmission blocking potency and immunogenicity of a plant-produced Pvs25-based subunit vaccine against Plasmodium vivax., PMID:27177945
Anticentromere antibody-positive primary Sjögren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients., PMID:27161330
Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation., PMID:25092915
Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests., PMID:24931955
Prevalence, diagnostic value and clinical characteristics associated with the presence of circulating levels and renal deposits of antibodies against the M-type phospholipase A2 receptor in idiopathic membranous nephropathy., PMID:24798555
Dynamic phosphorylation of HP1α regulates mitotic progression in human cells., PMID:24619172
Clinical significance of autoantibodies to the pericentromeric heterochromatin protein 1a protein., PMID:24184038
Protein A immunosensor for the detection of immunoglobulin G by impedance spectroscopy., PMID:24141418
p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity., PMID:23151508
Immunological evaluation of lipopeptide group A streptococcus (GAS) vaccine: structure-activity relationship., PMID:22253911
Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts., PMID:21364188
Serodiagnosis of borreliosis: indirect immunofluorescence assay, enzyme-linked immunosorbent assay and immunoblotting., PMID:21258869
HP1α is not necessary for the structural maintenance of centromeric heterochromatin., PMID:20962594
Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis., PMID:20955560
Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours., PMID:20695923
A very large C-loop in EGF domain IV is characteristic of the P28 family of ookinete surface proteins., PMID:19057932
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice., PMID:18606155
The heterochromatin protein 1 family is regulated in prostate development and cancer., PMID:18436254
Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2., PMID:18413606
Pre-Lamin A processing is linked to heterochromatin organization., PMID:17654502
[Recent research on the JC virus]., PMID:17380774
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases., PMID:17123092
The use of transgenic Plasmodium berghei expressing the Plasmodium vivax antigen P25 to determine the transmission-blocking activity of sera from malaria vaccine trials., PMID:17049690
Phosphorylation of the linker histone H1 by CDK regulates its binding to HP1alpha., PMID:16762841
Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting., PMID:16283356
Leptospiral proteins expressed during acute & convalescent phases of human leptospirosis., PMID:15489552
Histone modification in constitutive heterochromatin versus unexpressed euchromatin in human cells., PMID:15368356
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance., PMID:15215892
Serological description of Estonian patients with Lyme disease, a comparison with control sera from endemic and non-endemic areas., PMID:15147004
Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells., PMID:15048935
NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin., PMID:14742713
Analysis of egg antigens inducing hepatic lesions in schistosome infection., PMID:14665394
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns., PMID:14519686
Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase., PMID:12840071
HP1beta and HP1gamma, but not HP1alpha, decorate the entire XY body during human male meiosis., PMID:12675308
MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)., PMID:12079517
Immunolocalization of HP1 proteins in metaphasic mammalian chromosomes., PMID:11741155
Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists., PMID:11472212
Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation., PMID:11405226
HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes., PMID:11124534
Immunohistochemical versus molecular detection of RAK antigens in breast cancer., PMID:10891290