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Anti-Human CBX1 Polyclonal Antibody

Catalog #:   PHF75401 Specific References (23) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P83916
Overview

Catalog No.

PHF75401

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CBX1 (Glu24-Leu168).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HP1Hsbeta, CBX, Chromobox protein homolog 1, Modifier 1 protein, Heterochromatin protein 1 homolog beta, HP1 beta, M31, CBX1, p25beta, Heterochromatin protein p25

Purification

Purified by antigen affinity column.

Accession

P83916

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN-BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CBX1 antibody (PHF75401) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 19 kDa
    Observed MW: 19 kDa
References

Role of HP1β during spermatogenesis and DNA replication., PMID:32651609

Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-lymphoblastic leukemia/lymphoma., PMID:31776129

Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones., PMID:31634430

Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction., PMID:29464021

Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor., PMID:26364738

CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage., PMID:26158765

Non-radioactive protein lysine methyltransferase microplate assay based on reading domains., PMID:23671032

Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes., PMID:23269287

Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes., PMID:21239609

Age-associated increase in heterochromatic marks in murine and primate tissues., PMID:21176091

DNA synthesis and epigenetic modification during mouse oocyte fertilization by human or hamster sperm injection., PMID:21107900

Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1., PMID:18590578

The heterochromatin protein 1 family is regulated in prostate development and cancer., PMID:18436254

Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting., PMID:16283356

Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance., PMID:15215892

Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase., PMID:12840071

HP1beta and HP1gamma, but not HP1alpha, decorate the entire XY body during human male meiosis., PMID:12675308

Pim-1 associates with protein complexes necessary for mitosis., PMID:12111331

Immunolocalization of HP1 proteins in metaphasic mammalian chromosomes., PMID:11741155

HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes., PMID:11124534

M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis., PMID:10516442

Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells., PMID:10460410

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing., PMID:10330177

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Anti-Human CBX1 Polyclonal Antibody [PHF75401]
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