Catalog No.
PHF75401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CBX1 (Glu24-Leu168).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
HP1Hsbeta, CBX, Chromobox protein homolog 1, Modifier 1 protein, Heterochromatin protein 1 homolog beta, HP1 beta, M31, CBX1, p25beta, Heterochromatin protein p25
Purification
Purified by antigen affinity column.
Accession
P83916
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Role of HP1β during spermatogenesis and DNA replication., PMID:32651609
Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-lymphoblastic leukemia/lymphoma., PMID:31776129
Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones., PMID:31634430
Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction., PMID:29464021
Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor., PMID:26364738
CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage., PMID:26158765
Non-radioactive protein lysine methyltransferase microplate assay based on reading domains., PMID:23671032
Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes., PMID:23269287
Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes., PMID:21239609
Age-associated increase in heterochromatic marks in murine and primate tissues., PMID:21176091
DNA synthesis and epigenetic modification during mouse oocyte fertilization by human or hamster sperm injection., PMID:21107900
Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1., PMID:18590578
The heterochromatin protein 1 family is regulated in prostate development and cancer., PMID:18436254
Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting., PMID:16283356
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance., PMID:15215892
Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase., PMID:12840071
HP1beta and HP1gamma, but not HP1alpha, decorate the entire XY body during human male meiosis., PMID:12675308
Pim-1 associates with protein complexes necessary for mitosis., PMID:12111331
Immunolocalization of HP1 proteins in metaphasic mammalian chromosomes., PMID:11741155
HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes., PMID:11124534
M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis., PMID:10516442
Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells., PMID:10460410
KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing., PMID:10330177
For research use only. Not for human or drug use.
