Anti-Human PDE4A Polyclonal Antibody

Catalog No.

PHD75301

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PDE4A (Ser435-Ser686).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

DPDE2, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, PDE4A, PDE46

Purification

Purified by antigen affinity column.

Accession

P27815

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Pharmacogenetic biomarkers for secukinumab response in psoriasis patients in real-life clinical practice., PMID:38153843

Rolipram optimizes therapeutic effect of bevacizumab by enhancing proapoptotic, antiproliferative signals in a glioblastoma heterotopic model., PMID:31678282

Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape., PMID:29273118

Rolipram potentiates bevacizumab-induced cell death in human glioblastoma stem-like cells., PMID:28202289

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits., PMID:27818087

Expression and distribution of phosphodiesterase isoenzymes in the human male urethra., PMID:25704994

Identification of new signaling components in the sensory epithelium of human saccule., PMID:21886636

Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles., PMID:21810184

Transcriptome analysis and cytokine profiling of naive T cells stimulated by a tumor vaccine via CD3 and CD25., PMID:21042712

Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?, PMID:17113813

Naris occlusion alters transductory protein immunoreactivity in olfactory epithelium., PMID:16493579

AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa., PMID:16177223

Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue., PMID:15717866

Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells., PMID:15242814

Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey., PMID:11716814

Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects., PMID:11429397

Surgically induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic adenosine monophosphate-dependent phosphodiesterases type 4 in abdominal testes of rats., PMID:11369582

Noradrenergic lesions differentially alter the expression of two subtypes of low Km cAMP-sensitive phosphodiesterase type 4 (PDE4A and PDE4B) in rat brain., PMID:10837797

The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution., PMID:10829034

Distribution of PDE4A and G(o) alpha immunoreactivity in the accessory olfactory system of the mouse., PMID:10683824

Type 4 cyclic adenosine monophosphate-specific phosphodiesterases are expressed in discrete subcellular compartments during rat spermiogenesis., PMID:10218983

Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect., PMID:10213096

Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A., PMID:9754717

Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain., PMID:9443929

Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain., PMID:9375671

Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells., PMID:9337850

Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines., PMID:9003417

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B., PMID:8632354

Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists., PMID:7559525

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