Anti-Human HBP1 Polyclonal Antibody

Catalog No.

PHA89701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HBP1 (Arg220-Ser311).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HMG box transcription factor 1, HMG box-containing protein 1, High mobility group box transcription factor 1, HBP1

Purification

Purified by antigen affinity column.

Accession

O60381

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Unveiling the Therapeutic Potential of Dulaglutide in Mitigating Tacrolimus-Induced Nephrotoxicity Through Targeting the miR-22/HMGB-1/TLR4/MyD88/NF-κB Trajectory., PMID:40205909

HMGB1 drives T-cell activation in hypertensive males and females., PMID:39982439

Anti-HMGB1 mAb Therapy Reduces Epidural Hematoma Injury., PMID:38892076

Alirocumab boosts antioxidant status and halts inflammation in rat model of sepsis-induced nephrotoxicity via modulation of Nrf2/HO-1, PCSK9/HMGB1/NF-ᴋB/NLRP3 and Fractalkine/CX3CR1 hubs., PMID:38889644

Berberine Improves Cancer-Derived Myocardial Impairment in Experimental Cachexia Models by Targeting High-Mobility Group Box-1., PMID:38731953

Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay., PMID:38608546

HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism., PMID:37833459

Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor., PMID:36275732

Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis <em>via</em> NF-κB signaling pathway., PMID:35726537

In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines., PMID:34990474

Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling., PMID:34764638

Celastrol Exerts Cardioprotective Effect in Rheumatoid Arthritis by Inhibiting TLR2/HMGB1 Signaling Pathway-Mediated Autophagy., PMID:34428765

HMGB1 released from nociceptors mediates inflammation., PMID:34385304

HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia/reperfusion-induced acute renal damage., PMID:33745733

HMGB1/RAGE/TLR4 axis and glutamate as novel targets for PCSK9 inhibitor in high fat cholesterol diet induced cognitive impairment and amyloidosis., PMID:33667517

High-mobility group box-1 and inter-alpha inhibitor proteins: In vitro binding and co-localization in cerebral cortex after hypoxic-ischemic injury., PMID:33559227

Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain., PMID:32971090

Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway., PMID:32301050

Bioactive fractions from Securidaca inappendiculata alleviated collagen-induced arthritis in rats by regulating metabolism-related signaling., PMID:32187848

Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats., PMID:31879851

TNF-α-elicited miR-29b potentiates resistance to apoptosis in peripheral blood monocytes from patients with rheumatoid arthritis., PMID:31473844

High mobility group box 1 protein released in the course of aseptic necrosis of tissues sensitizes rats to pyrogenic effects of lipopolysaccharide., PMID:31466775

Anti-high mobility group box-1 antibody attenuated vascular smooth muscle cell phenotypic switching and vascular remodelling after subarachnoid haemorrhage in rats., PMID:31226363

HMGB1-modified mesenchymal stem cells attenuate radiation-induced vascular injury possibly via their high motility and facilitation of endothelial differentiation., PMID:30867070

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling., PMID:30728013

HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension., PMID:30517029

[The role of high-mobility group box protein 1 in the signaling pathways of myocardial ischemia-reperfusion injury in rats]., PMID:30392294

Anti-High Mobility Group Box 1 Antibody Therapy May Prevent Cognitive Dysfunction After Traumatic Brain Injury., PMID:30391757

Acute pulmonary effects of aerosolized nicotine., PMID:30358437

High mobility group box-1 in hypothalamic paraventricular nuclei attenuates sympathetic tone in rats at post-myocardial infarction., PMID:30338842

HMGB1 Neutralization Attenuates Hippocampal Neuronal Death and Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion via Suppressing Inflammatory Responses and Oxidative Stress., PMID:29777754

Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model., PMID:29395422

HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation., PMID:29355710

Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis., PMID:29096648

Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1., PMID:29046479

High Mobility Group Box 1 Mediates Interferon-γ-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells., PMID:27579780

Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats., PMID:27474498

Blockade of Extracellular High-Mobility Group Box 1 Attenuates Systemic Inflammation and Coagulation Abnormalities in Rats with Acute Traumatic Coagulopathy., PMID:27436061

Ketamine attenuates sepsis-induced acute lung injury via regulation of HMGB1-RAGE pathways., PMID:26945830

High-mobility group box 1 induces neuron autophagy in a rat spinal root avulsion model., PMID:26705737

Anti-high mobility group box 1 monoclonal antibody improves ischemia/reperfusion injury and mode of liver regeneration after partial hepatectomy., PMID:26409302

The role of high mobility group box 1 (HMGB-1) in the diabetic retinopathy inflammation and apoptosis., PMID:26261566

Tanshinone IIA Attenuates Chronic Pancreatitis-Induced Pain in Rats via Downregulation of HMGB1 and TRL4 Expression in the Spinal Cord., PMID:26218952

Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis., PMID:25452436

HMGB1 promotes the development of pulmonary arterial hypertension in rats., PMID:25032709

Oxygen glucose deprivation/reperfusion astrocytes promotes primary neural stem/progenitor cell proliferation by releasing high-mobility group box 1., PMID:24838617

H2O2 evokes injury of cardiomyocytes through upregulating HMGB1., PMID:24681787

Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice., PMID:24361123

Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition., PMID:24133029

Intrathecal lentivirus-mediated transfer of interleukin-10 attenuates chronic constriction injury-induced neuropathic pain through modulation of spinal high-mobility group box 1 in rats., PMID:24077211

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