Catalog No.
PHC82201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CYP2C8 (Gly40-Val490).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CYP2C8, Cytochrome P450 MP-12, Cytochrome P450 IIC2, Cytochrome P450 MP-20, Cytochrome P450 2C8, CYPIIC8, S-mephenytoin 4-hydroxylase, Cytochrome P450 form 1
Purification
Purified by antigen affinity column.
Accession
P10632
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeted Metabolomics Study of Human Plasma Revealed Activation of the Cytochrome P450 Epoxygenase/Epoxide Hydrolase Axis in Patients with IgA Nephropathy., PMID:36301320
Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status., PMID:36113565
Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes., PMID:32131538
Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression., PMID:31706844
Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism., PMID:29203276
The Inhibitory Effect of Telmisartan on the Metabolism of Arachidonic Acid by CYP2C9 and CYP2C8: An in Vitro Study., PMID:28867723
Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes., PMID:27924364
Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients., PMID:27334415
Differential expression of cytochrome P450 enzymes from the CYP2C subfamily in the human brain., PMID:25504503
Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry., PMID:23434495
In vitro characterization of the drug-drug interaction potential of catabolites of antibody-maytansinoid conjugates., PMID:22752008
Identification of human cytochrome P450 enzymes involved in the metabolism of a novel к-opioid receptor agonist, nalfurafine hydrochloride., PMID:22581509
Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case., PMID:21178300
Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation., PMID:20825389
Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists., PMID:20804500
Transplacental transfer and metabolism of buprenorphine in preterm human placenta., PMID:20607647
In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism., PMID:20595377
Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide., PMID:19679108
Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes., PMID:19663817
In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes., PMID:19336906
Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry., PMID:18828626
Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro., PMID:18787056
In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes., PMID:17701830
In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies., PMID:17565714
Hepatic metabolism of MK-0457, a potent aurora kinase inhibitor: interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase., PMID:17537870
Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar., PMID:17062778
Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype., PMID:16945988
Catalytic assays for human cytochrome P450: an introduction., PMID:16719375
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.)., PMID:16611861
Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar)., PMID:16443667
Catalytic Assays for Human Cytochrome P450 : An Introduction., PMID:27699679
Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone., PMID:15619261
Production of inhibitory polyclonal antibodies against cytochrome P450s., PMID:15618732
Studies on the metabolic fate of M17055, a novel diuretic (4): species difference in metabolic pathway and identification of human CYP isoform responsible for the metabolism of M17055., PMID:15618654
Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants., PMID:15543094
Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19., PMID:15448116
CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes., PMID:15319333
Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes., PMID:15100167
Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro., PMID:15054565
CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification., PMID:14985143
CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide., PMID:12919179
The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6., PMID:12848784
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices., PMID:12584154
Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA., PMID:12107550
Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19., PMID:12019193
Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes., PMID:11950794
Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism., PMID:11950782
Phosphonate O-deethylation of [4-(4-bromo-2-cyano-phenylcarbamoyl) benzyl]-phosphonic acid diethyl ester, a lipoprotein lipase-promoting agent, catalyzed by cytochrome P450 2C8 and 3A4 in human liver microsomes., PMID:11854149
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes., PMID:11602525
Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama)., PMID:11551531
For research use only. Not for human or drug use.
