Catalog No.
PHE29701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CASR (Tyr63-Ser531).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Parathyroid cell calcium-sensing receptor 1, CaR, Extracellular calcium-sensing receptor, PCAR1, GPRC2A, PCaR1, CASR, hCasR, CaSR
Purification
Purified by antigen affinity column.
Accession
P41180
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism., PMID:40492090
An Extremely Rare Case of Immune Checkpoint Inhibitors-Related Hypoparathyroidism and a Critical Literature Review., PMID:40356787
Biased antibodies and beyond: a new era in the diagnosis of PTH-dependent hypercalcemia., PMID:40335290
Endocytotic Albumin Uptake Pathways in Human Adipose Stem Cells and Connection to Intracellular Calcium Oscillations and the Neonatal Fc receptor., PMID:40239638
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation., PMID:39791147
Hypoxia Microenvironment Preconditioning Attenuated Myocardial Ischemia-Reperfusion Injury via Stc1-Mediating Cardiomyocyte Self-Protection and Neutrophil Polarization., PMID:39676707
Detailed functional characterization of four nanobodies as positive allosteric modulators of the human calcium-sensing receptor., PMID:39522703
Early divergent modulation of NLRP2's and NLRP3's inflammasome sensors vs. AIM2's one by signals from Aβ·Calcium-sensing receptor complexes in human astrocytes., PMID:39426463
Silicon-Rhodamine Functionalized Evocalcet Probes Potently and Selectively Label Calcium Sensing Receptors In Vitro, In Vivo, and Ex Vivo., PMID:38751613
TRPC3 Is Downregulated in Primary Hyperparathyroidism., PMID:38673977
Nanobodies as negative allosteric modulators for human calcium sensing receptor., PMID:38154264
Seizures in activating calcium-sensing receptor antibodies positive autoimmune hypoparathyroidism and preponderance of steroids therapy: A case report., PMID:36789314
The role of calcium-sensitive receptor in ovalbumin-induced airway inflammation and hyperresponsiveness in juvenile mice with asthma., PMID:36169192
Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused by biased allosteric CaSR autoantibodies., PMID:36099030
Rare ocular toxicity induced by pertuzumab/QL1209 in healthy chinese subjects: case reports and whole-exome sequencing analysis., PMID:35596833
Ectopic parathyroid hormone as a rare aetiology of hypercalcemia with rhabdomyosarcoma: a new treatment strategy with zoledronic acid and Denosumab., PMID:35534911
Filamin A and parafibromin expression in parathyroid carcinoma., PMID:34606470
A study of altered calcium sensing system caused primary membranous nephropathy to end-stage renal failure., PMID:34246186
Late diagnosis of chronic hypocalcemia due to autoimmune hypoparathyroidism., PMID:34193455
Salinity-dependent expression of calcium-sensing receptors in Atlantic salmon (Salmo salar) tissues., PMID:34114081
Calhex231 ameliorates myocardial fibrosis post myocardial infarction in rats through the autophagy-NLRP3 inflammasome pathway in macrophages., PMID:33043596
c-Met expression in renal cell carcinoma with bone metastases., PMID:33024658
Efficient detection of eukaryotic calcium-sensing receptor (CaSR) by polyclonal antibody against prokaryotic expressed truncated CaSR., PMID:33001312
Calcium-sensing receptor autoantibody-mediated hypoparathyroidism associated with immune checkpoint inhibitor therapy: diagnosis and long-term follow-up., PMID:32581059
CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes., PMID:32498476
Autoimmune Hypercalcemia Due to Autoantibodies Against the Calcium-sensing Receptor., PMID:32311038
Calcilytics: a non-steroidal replacement for inhaled steroid and SABA/LABA therapy of human asthma?, PMID:32306788
Activating Antibodies to The Calcium-sensing Receptor in Immunotherapy-induced Hypoparathyroidism., PMID:32112105
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1-/- mice., PMID:31603369
Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody., PMID:30996138
Calcium-Sensing Receptor Autoantibodies in Patients with Autoimmune Polyendocrine Syndrome Type 1: Epitopes, Specificity, Functional Affinity, IgG Subclass, and Effects on Receptor Activity., PMID:30381479
Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor., PMID:30358904
Immune Checkpoint Inhibitor-Induced Hypoparathyroidism Associated With Calcium-Sensing Receptor-Activating Autoantibodies., PMID:30252069
Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites., PMID:29576437
Prolonged exposure to 1,25(OH)2D3 and high ionized calcium induces FGF-23 production in intestinal epithelium-like Caco-2 monolayer: A local negative feedback for preventing excessive calcium transport., PMID:29317227
Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation., PMID:29050010
Autoantibodies against the calcium-sensing receptor and cytokines in autoimmune polyglandular syndromes types 2, 3 and 4., PMID:28941288
Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation., PMID:28915604
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced nitric oxide production and vasorelaxation in rabbit mesenteric arteries., PMID:28867591
Glucocorticoid-responsive lymphocytic parathyroiditis and hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor: a case report and literature review., PMID:28515208
Diseases associated with calcium-sensing receptor., PMID:28122587
External Ca2+ regulates polycystin-2 (TRPP2) cation currents in LLC-PK1 renal epithelial cells., PMID:27836810
Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein., PMID:27450451
Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016., PMID:27294413
Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney., PMID:26661650
GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses., PMID:26602597
Auto-immune hypoparathyroidism., PMID:25913523
Supplementation of strontium to a chondrogenic medium promotes chondrogenic differentiation of human dedifferentiated fat cells., PMID:25669848
Effect of fasting and refeeding on expression of genes involved in the gastric nutrient sensing and orexigenic control of pigs., PMID:25491185
For research use only. Not for human or drug use.
