Catalog No.
PHK41701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RUVBL2 (Gln49-Ser463).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
48 kDa TATA box-binding protein-interacting protein, RuvB-like 2, INO80 complex subunit J, RUVBL2, TAP54-beta, Reptin 52, TIP60-associated protein 54-beta, TIP48, TIP49B, 51 kDa erythrocyte cytosolic protein, 48 kDa TBP-interacting protein, Repressing pontin 52, INO80J, TIP49b, ECP-51
Purification
Purified by antigen affinity column.
Accession
Q9Y230
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Detection of Anti-RuvBL1/2 Autoantibodies by Targeted Liquid Chromatography-Tandem Mass Spectrometry., PMID:40498123
Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies against self-antigens., PMID:37751306
Leishmania major RUVBL1 has a hexameric conformation in solution and, in the presence of RUVBL2, forms a heterodimer with ATPase activity., PMID:33775623
Pathogenic roles of autoantibodies in systemic sclerosis: Current understandings in pathogenesis., PMID:35382028
A case of anti-RuvBL1/2 antibody-positive systemic sclerosis overlapping with myositis., PMID:32031537
Critical Role of Macrophage FcγR Signaling and Reactive Oxygen Species in Alloantibody-Mediated Hepatocyte Rejection., PMID:30397035
Prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma - A review., PMID:30316987
Presence of anti-eukaryotic initiation factor-2B, anti-RuvBL1/2 and anti-synthetase antibodies in patients with anti-nuclear antibody negative systemic sclerosis., PMID:29294089
What is the third serological marker associated with immune-mediated necrotizing myopathy?, PMID:28067601
Case of anti-RuvBL1/2 antibody-positive morphea and polymyositis., PMID:27786369
An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex., PMID:25312759
Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement., PMID:24023044
Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein., PMID:23780840
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity., PMID:22761313
Reptin52 expression during in vitro neural differentiation of human embryonic stem cells., PMID:19444951
TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human., PMID:9588198
For research use only. Not for human or drug use.
