Catalog No.
PHB04801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RNASEH1 (Asp138-Asp286).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
RNase H1, RNASEH1, RNH1, Ribonuclease H type II, Ribonuclease H1
Purification
Purified by antigen affinity column.
Accession
O60930
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia., PMID:32447804
Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia., PMID:31798789
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1., PMID:30996261
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice., PMID:30345028
RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia., PMID:29204916
Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis., PMID:22346767
For research use only. Not for human or drug use.
