Catalog No.
PHA25402
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DVL2 (Asn264-Lys353).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Dishevelled-2, DVL2, DSH homolog 2, Segment polarity protein dishevelled homolog DVL-2
Purification
Purified by antigen affinity column.
Accession
O14641
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis., PMID:31465125
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy., PMID:30510196
Wnt5a Contributes to the Differentiation of Human Embryonic Stem Cells into Lentoid Bodies Through the Noncanonical Wnt/JNK Signaling Pathway., PMID:30025083
Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway., PMID:28187436
Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia., PMID:27086035
An unconventional KITENIN/ErbB4-mediated downstream signal of EGF upregulates c-Jun and the invasiveness of colorectal cancer cells., PMID:24893630
High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner., PMID:24427302
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling., PMID:23396967
The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo., PMID:21618643
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation., PMID:20639871
Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression., PMID:18692936
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3., PMID:18093802
Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease., PMID:17671721
Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation., PMID:16446366
WNT/PCP signaling pathway and human cancer (review)., PMID:16273260
The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling., PMID:15507471
Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription., PMID:10329628
WNT signaling in the control of hair growth and structure., PMID:10049570
Human dishevelled genes constitute a DHR-containing multigene family., PMID:9192851
For research use only. Not for human or drug use.
