Catalog No.
PHG54301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ROCK1 (Met1-Thr351).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Renal carcinoma antigen NY-REN-35, p160 ROCK-1, p160ROCK, Rho-associated protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, Rho-associated, coiled-coil-containing protein kinase 1, ROCK-I, ROCK1
Purification
Purified by antigen affinity column.
Accession
Q13464
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis., PMID:40360692
ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI., PMID:39903532
Isobutyric Acid Promotes Immune Evasion in Colorectal Cancer via Increased PD-L1 Expression., PMID:39503247
The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma., PMID:39307412
Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients., PMID:38389037
Modulating asthma-COPD overlap responses with IL-17 inhibition., PMID:37965351
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19., PMID:36881624
MicroRNA-148a induces apoptosis and prevents angiogenesis with bevacizumab in colon cancer through direct inhibition of ROCK1/c-Met via HIF-1α under hypoxia., PMID:35997665
An Agonistic Monoclonal Antibody Targeting cMet Attenuates Inflammation and Up-Regulates Collagen Synthesis and Angiogenesis in Type 2 Diabetic Mice Wounds., PMID:35759635
CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome., PMID:35370759
Dual efficacy of Fasudil at improvement of survival and reinnervation of flap through RhoA/ROCK/PI3K/Akt pathway., PMID:35315211
Silencing ROCK1 ameliorates ventilator-induced lung injury in mice by inhibiting macrophages' NLRP3 signaling., PMID:34619496
Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease., PMID:33799579
Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies., PMID:33587338
Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation., PMID:33357114
Identification and characterization of a new isoform of small GTPase RhoE., PMID:33060740
Arctiin attenuates high glucose-induced human retinal capillary endothelial cell proliferation by regulating ROCK1/PTEN/PI3K/Akt/VEGF pathway in vitro., PMID:32297701
Profilin 1 knockdown prevents ischemic brain damage by promoting M2 microglial polarization associated with the RhoA/ROCK pathway., PMID:32291804
Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF-Resistant Diabetic Macular Edema., PMID:32139595
mRNA level of ROCK1, RHOA, and LIMK2 as genes associated with apoptosis in evaluation of effectiveness of adalimumab treatment., PMID:32124389
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4., PMID:31618077
Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection., PMID:31320595
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway., PMID:31150636
Loss of ARHGEF1 causes a human primary antibody deficiency., PMID:30521495
Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma., PMID:30233389
Histamine causes endothelial barrier disruption via Ca2+-mediated RhoA activation and tension at adherens junctions., PMID:30185878
The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity., PMID:30030370
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer., PMID:29382705
CXCL16/ROCK1 signaling pathway exacerbates acute kidney injury induced by ischemia-reperfusion., PMID:29275176
Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers., PMID:29024000
ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy., PMID:28821742
Therapeutic effects of long-circulating miR-135a-containing cationic immunoliposomes against gallbladder carcinoma., PMID:28729631
RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro., PMID:28225457
Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy., PMID:28112365
Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization., PMID:27877086
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus., PMID:27764233
Melanoma-expressed CD70 is involved in invasion and metastasis., PMID:26671750
Immunohistochemical evaluation of ROCK activation in invasive breast cancer., PMID:26626121
Rho-kinase expression in Hirschsprung's disease., PMID:26276426
Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study., PMID:25971815
Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2., PMID:25827955
TBCRC 019: A Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel with or without the Anti-Death Receptor 5 Monoclonal Antibody Tigatuzumab in Patients with Triple-Negative Breast Cancer., PMID:25779953
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway., PMID:25779535
Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles., PMID:25637593
Hyaluroan-regulated lymphatic permeability through S1P receptors is crucial for cancer metastasis., PMID:25428387
Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency., PMID:25323425
Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats., PMID:24948002
Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology., PMID:24349032
Involvement of PtdIns(4,5)P2 in the regulatory mechanism of small intestinal P-glycoprotein expression., PMID:24311454
Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation., PMID:24309928
For research use only. Not for human or drug use.
