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Anti-Human SPOP Polyclonal Antibody

Catalog #:   PHA78201 Specific References (17) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: O43791
Overview

Catalog No.

PHA78201

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SPOP (Ser21-Thr175).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Roadkill homolog 1, HIB homolog 1, SPOP, Speckle-type POZ protein

Purification

Purified by antigen affinity column.

Accession

O43791

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN-BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with SPOP antibody (PHA78201) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 20 kDa
    Observed MW: 20 kDa
References

Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer., PMID:39499771

Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1., PMID:38953362

Neural Stem Cell Extracellular Vesicles Carrying YBX1 Inhibited Neuronal Pyroptosis Through Increasing m6A-modified GPR30 Stability and Expression in Ischemic Stroke., PMID:37966628

Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy., PMID:36514940

BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade., PMID:34615996

The establishment of an immunosensor for the detection of SPOP., PMID:34131189

Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression., PMID:34026438

Loss of Speckle-Type POZ Protein Promotes Prostate Cancer Cell Migration and Invasion Through Upregulation of MCP-1., PMID:33872295

NCOR1 may be a potential biomarker of a novel molecular subtype of prostate cancer., PMID:33058520

Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer., PMID:32941674

ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer., PMID:31772275

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly., PMID:31771591

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer., PMID:29906450

Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients., PMID:26863016

Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins., PMID:26373678

Speckle-type POZ protein, SPOP, is involved in the DNA damage response., PMID:24451148

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation., PMID:20154143

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Anti-Human SPOP Polyclonal Antibody [PHA78201]
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