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Anti-Human SAMHD1 Polyclonal Antibody

Catalog #:   PHK36201 Specific References (34) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q9Y3Z3
Overview

Catalog No.

PHK36201

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SAMHD1 (Asp41-Asp583).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

SAM domain and HD domain-containing protein 1, DCIP, Monocyte protein 5, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MOP5, hSAMHD1, dNTPase, Dendritic cell-derived IFNG-induced protein, MOP-5, SAMHD1

Purification

Purified by antigen affinity column.

Accession

Q9Y3Z3

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN-BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with SAMHD1 antibody (PHK36201) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 65 kDa
    Observed MW: 65 kDa
References

Prognostic impact of genetic abnormalities in 536 first-line chronic lymphocytic leukaemia patients without 17p deletion treated with chemoimmunotherapy in two prospective trials: Focus on IGHV-mutated subgroups (a FILO study)., PMID:38654616

HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819., PMID:36309692

SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide., PMID:34893529

Nucleotide Pool Imbalance and Antibody Gene Diversification., PMID:34696158

Restriction Factor Expression in Vertically Infected Children Living With HIV-1., PMID:33395209

Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity., PMID:33224139

The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial., PMID:32638373

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes., PMID:32584970

SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination., PMID:32511795

Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity., PMID:31178863

Multiple Autoimmune Disorders in Aicardi-Goutières Syndrome., PMID:30898416

SAMHD1 Suppression of Antiviral Immune Responses., PMID:30336972

[Familial chilblain lupus: Four cases spanning three generations]., PMID:30217686

SAMHD1 deficient human monocytes autonomously trigger type I interferon., PMID:30099227

DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci., PMID:29614270

DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1., PMID:29515139

Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension., PMID:28935667

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups., PMID:28584254

Tocilizumab reverses cerebral vasculopathy in a patient with homozygous SAMHD1 mutation., PMID:28289923

Development of monoclonal antibodies specifically recognizing the endogenous sterile alpha motif and HD domain 1 protein in porcine cell lines., PMID:25358004

Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry., PMID:25329145

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers., PMID:25063780

Broadly neutralizing antibody VRC01 prevents HIV-1 transmission from plasmacytoid dendritic cells to CD4 T lymphocytes., PMID:24965460

17β-estradiol protects primary macrophages against HIV infection through induction of interferon-alpha., PMID:24801776

Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cells., PMID:24574390

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study., PMID:24183309

Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1., PMID:23966382

HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx., PMID:23924154

Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities., PMID:23786957

Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease., PMID:23630526

Innate immune sensing of HIV-1 by dendritic cells., PMID:23084911

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations., PMID:22461318

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome., PMID:20131292

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants., PMID:12107410

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-Human SAMHD1 Polyclonal Antibody [PHK36201]
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