Anti-Human ZEB1 Polyclonal Antibody

Catalog No.

PHE21501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ZEB1 (Ser583-Glu643).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Transcription factor 8, NIL-2-A zinc finger protein, Zinc finger E-box-binding homeobox 1, ZEB1, Negative regulator of IL2, TCF-8, TCF8, AREB6

Purification

Purified by antigen affinity column.

Accession

P37275

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

ERK2-mediated phosphorylation of ZEB1 at S322 enhances PD-L1 expression and EMT, leading to pancreatic cancer progression., PMID:40296122

Microglial repopulation alleviates surgery-induced neuroinflammation and cognitive impairment in a ZEB1-dependent manner., PMID:40052833

Immunohistochemical Analysis of Inter-Alpha-Trypsin Inhibitor Heavy Chain 2 and Enolase 1 in Canine Mammary Tumors: Associations with Tumor Aggressiveness and Prognostic Significance., PMID:40005870

The Impact of Bevacizumab and miR200c on EMT and EGFR-TKI Resistance in EGFR-Mutant Lung Cancer Organoids., PMID:39766891

Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation., PMID:39736693

Isoliquiritigenin Suppresses Breast Tumor Development by Enhancing Host Antitumor Immunity., PMID:39343993

Targeting ITGβ3 to Overcome Trastuzumab Resistance through Epithelial-Mesenchymal Transition Regulation in HER2-Positive Breast Cancer., PMID:39201327

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer., PMID:39191092

A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis., PMID:38968684

Inhibition of PD-L1 expression in non-small cell lung cancer may reduce vasculogenic mimicry formation by inhibiting the epithelial mesenchymal transformation process., PMID:38508327

Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma., PMID:38378697

Unravelling heterogeneous effects of cancer‑associated fibroblasts on poor prognosis markers in breast cancer EM‑G3 cell line: In vitro‑targeted treatment (anti‑IL-6, anti‑VEGF-A, anti‑MFGE8) based on transcriptomic profiling., PMID:37975220

Multi-kinase compensation rescues EGFR knockout in a cell line model of head and neck squamous cell carcinoma., PMID:37844343

Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition and aggressive behaviors of human head and neck cancer., PMID:37787967

Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition., PMID:37722568

Epigenetically upregulating TROP2 and SLFN11 enhances therapeutic efficacy of TROP2 antibody drug conjugate sacitizumab govitecan., PMID:37567892

Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy., PMID:37398248

CUL4A-mediated ZEB1/microRNA-340-5p/HMGB1 axis promotes the development of osteoporosis., PMID:37253097

Pirfenidone suppressed triple-negative breast cancer metastasis by inhibiting the activity of the TGF-β/SMAD pathway., PMID:36651490

Plasma and Peritoneal Fluid ZEB Levels in Patients with Endometriosis and Infertility., PMID:36289723

Expression of HnRNP A1, ZEB1, and E-cadherin in Hepatocellular carcinoma and their impact on patients' prognosis and survival., PMID:35900486

Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis., PMID:35589690

ZEB1 transcription factor promotes immune escape in melanoma., PMID:35288462

Association of PD-L1 and ZEB-1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma., PMID:35111244

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation., PMID:35078508

Role of the Immunohistochemical ZEB1 Expression in Uterine Mesenchymal Neoplasms., PMID:34994578

Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that promotes ovarian cancer growth, invasion, cisplatin resistance and spheroid formation., PMID:34942534

Neutrophil extracellular traps drive epithelial-mesenchymal transition of human colon cancer., PMID:34939675

Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo., PMID:34302038

Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis., PMID:34257516

COVID-19 patients' sera induce epithelial mesenchymal transition in cancer cells., PMID:34090218

The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma., PMID:34076685

Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells., PMID:34074001

Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells., PMID:33692626

Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing., PMID:33627322

Proteomic analysis of radio-resistant breast cancer xenografts: Increased TGF-β signaling and metabolism., PMID:33325135

Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives., PMID:33297475

Transcriptional profiles along cell programming into corneal epithelial differentiation., PMID:33098888

Hypoxia improved vasculogenesis in distraction osteogenesis through Mesenchymal-Epithelial transition (MET), Wnt/β-catenin signaling pathway, and autophagy., PMID:32778247

Wnt signaling and Loxl2 promote aggressive osteosarcoma., PMID:32686768

Long noncoding RNA ZEB1-AS1 acts as a Sponge of miR-141-3p to Inhibit Cell Proliferation in Colorectal Cancer., PMID:32669962

Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance., PMID:32041837

Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies., PMID:32039918

Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells., PMID:31982829

PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1., PMID:31828042

Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity., PMID:31331982

Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR., PMID:31281520

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment., PMID:31263103

Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework., PMID:31222037

Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling., PMID:30744595

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