Catalog No.
YHK80001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala96-Asp325
Predicted molecular weight
29.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H1P3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ORP-2, Oxysterol-binding protein-related protein 2, ORP2, OSBPL2, KIAA0772, OSBP-related protein 2
Defective autophagy in a fibroin secretion-deficient silkworm mutant., PMID:40413758
OSBPL2 deficiency inhibits Rho/ROCK2/p-ERM signaling and impairs actin cytoskeletal regulation in auditory cells., PMID:40391522
OSBPL2 inhibition leads to apoptosis of cochlea hair cells in age-related hearing loss by inhibiting the AKT/FOXG1 signaling pathway., PMID:39475791
Mutation spectrum of hearing loss patients in Northwest China: Identification of 20 novel variants., PMID:38860500
OSBPL2 compound heterozygous variants cause dyschromatosis, ichthyosis, deafness and atopic disease syndrome., PMID:38701954
Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression., PMID:38267463
Whole-genome resequencing of major populations revealed domestication-related genes in yaks., PMID:38233755
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis., PMID:37774976
The expression, immune infiltration, prognosis, and experimental validation of OSBPL family genes in liver cancer., PMID:36918840
Searching for the Molecular Basis of Partial Deafness., PMID:35682719
Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype., PMID:35525372
circRNA Acbd6 promotes neural stem cell differentiation into cholinergic neurons via the miR-320-5p-Osbpl2 axis., PMID:35305988
OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin., PMID:35253614
Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling., PMID:35041619
Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins., PMID:34864207
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma., PMID:34829830
The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells., PMID:34777295
ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange., PMID:34124795
Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin., PMID:34001864
Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis., PMID:33854310
Identification of candidate SNPs and genes associated with anti-RGNNV using GWAS in the red-spotted grouper, Epinephelus akaara., PMID:33609701
ORP2, a cholesterol transporter, regulates angiogenic signaling in endothelial cells., PMID:32914503
ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs., PMID:32734583
OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis., PMID:32650117
Comparative transcriptome analysis of auditory OC-1 cells and zebrafish inner ear tissues in the absence of human OSBPL2 orthologues., PMID:31629475
OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., PMID:31451425
Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity., PMID:31427568
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway., PMID:31356817
A novel pathogenic variant in OSBPL2 linked to hereditary late-onset deafness in a Mongolian family., PMID:30894143
OSBP-related protein 2 (ORP2): Unraveling its functions in cellular lipid/carbohydrate metabolism, signaling and F-actin regulation., PMID:30716465
ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol., PMID:30590084
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)., PMID:30581148
25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway., PMID:30391516
OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism., PMID:29947926
Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding., PMID:29930082
Analysis of ORP2-knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation., PMID:29092904
Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study., PMID:27917915
Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development., PMID:27063776
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis., PMID:26992564
ADRM1-amplified metastasis gene in gastric cancer., PMID:26052681
OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67)., PMID:25759012
Ligand-dependent localization and function of ORP-VAP complexes at membrane contact sites., PMID:25420878
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing., PMID:25077649
A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human., PMID:24326072
cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells., PMID:23325789
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype., PMID:23028956
Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells., PMID:21062391
Oxysterol-binding proteins., PMID:20213544
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism., PMID:19554302
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids., PMID:19224871
For research use only. Not for human or drug use.
