Catalog No.
YHJ30302
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys111
Predicted molecular weight
32.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WWM9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histoglobin, CYGB, Stellate cell activation-associated protein, Cytoglobin, STAP, HGb
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature., PMID:40252320
Electronic cigarette vape decreases nitric oxide bioavailability in vascular smooth muscle cells via increased cytoglobin-mediated metabolism., PMID:39743029
Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies., PMID:39630160
Cytoglobin augments ferroptosis through autophagic degradation of ferritin in colorectal cancer cells., PMID:39503803
Cytoglobin attenuates melanoma malignancy but protects melanoma cells from ferroptosis., PMID:39370785
AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway., PMID:39316687
SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis., PMID:39227479
The cytoglobin-dependent transcriptome in melanoma indicates a protective function associated with oxidative stress, inflammation and cancer-associated pathways., PMID:39107431
Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor- and Cygb-associated signaling pathways., PMID:39105365
Investigating Cytoglobin Expression in Colon Cancer: Clinicopathological Insights from Immunohistochemical Analysis., PMID:38307547
Molecular analysis of the human cytoglobin mRNA isoforms., PMID:38016326
Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain., PMID:37977965
Functional study of Cygb in the immune response to Vibrio harveyi disease in yellow drum (Nibea albiflora)., PMID:37951319
Engineering neuroglobin nitrite reductase activity based on myoglobin models., PMID:37929291
Cytoglobin functions as a redox regulator of melanogenesis in normal epidermal melanocytes., PMID:37920136
Insights into the function of cytoglobin., PMID:37721133
Vitamin D may assist the UPR against sodium fluoride-induced damage by reducing RIPK1, ATG5, BECN1, oxidative stress and increasing caspase-3 in the osteoblast MC3T3-E1 cell line., PMID:37677921
Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis., PMID:37573836
The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response., PMID:37549740
TFRC-RNA interactions show the regulation of gene expression and alternative splicing associated with IgAN in human renal tubule mesangial cells., PMID:37547464
Isolated Diaphorase From Bovine Erythrocyte Cannot Reduce Oxidized Cytoglobin (Metcygb)., PMID:36164636
Redox and spectroscopic properties of mammalian nitrite reductase-like hemoproteins., PMID:36116154
Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes., PMID:36112670
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response., PMID:36009267
Human Placental Extract Delays In Vitro Cellular Senescence through the Activation of NRF2-Mediated Antioxidant Pathway., PMID:36009264
Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response., PMID:35850009
Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion., PMID:35334247
Protective role of Cytoglobin and Neuroglobin against the Lipopolysaccharide (LPS)-induced inflammation in Leydig cells ex vivo., PMID:35121559
Cytoglobin has potent superoxide dismutase function., PMID:34930834
Role of cytoglobin in cigarette smoke constituent-induced loss of nitric oxide bioavailability in vascular smooth muscle cells., PMID:34875385
Cell-subpopulation alteration and FGF7 activation regulate the function of tendon stem/progenitor cells in 3D microenvironment revealed by single-cell analysis., PMID:34810035
Cytoglobin as a Prognostic Factor for Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis of 75 Patients., PMID:34629450
Reduction of oxidative stress and inflammatory signaling in the commissural nucleus of the solitary tract (commNTS) and rostral ventrolateral medulla (RVLM) in treadmill trained rats., PMID:34314729
A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma., PMID:34035373
Is the Mitochondrial Function of Keloid Fibroblasts Affected by Cytoglobin?, PMID:33958959
Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin., PMID:33649799
Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells., PMID:33611811
Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species., PMID:33576020
Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways., PMID:33522649
Defining the reducing system of the NO dioxygenase cytoglobin in vascular smooth muscle cells and its critical role in regulating cellular NO decay., PMID:33334890
Ginsenoside ameliorated ventilator-induced lung injury in rats., PMID:33292607
Inhibition of Renal Stellate Cell Activation Reduces Renal Fibrosis., PMID:33086608
Cytoglobin-expressing cells in the splenic cords contribute to splenic fibrosis in cirrhotic patients., PMID:32945524
Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis., PMID:32945464
Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions., PMID:32913582
A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer., PMID:32908121
DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis., PMID:32863941
Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport., PMID:32863222
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis., PMID:32492766
Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate Its Function in Molecular Basis., PMID:32461519
For research use only. Not for human or drug use.
