Catalog No.
YHE16301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly198
Predicted molecular weight
24.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35913
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GMP-PDE beta, PDEB, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, PDE6B
Mechanisms of photoreceptor protection upon targeting the Nrl-Nr2e3 pathway., PMID:40397675
Subretinal delivery of AAV5-mediated human Pde6b gene ameliorates the disease phenotype in a rat model of retinitis pigmentosa., PMID:40384764
Identifying a role for oxytosis/ferroptosis in Pde6b-associated retinitis pigmentosa., PMID:40379200
Voluntary running partially prevents photoreceptor cell death in retinitis pigmentosa., PMID:40352907
In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa., PMID:40064881
Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model., PMID:40016767
Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review., PMID:40013354
A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina., PMID:39745676
dCasMINI-mediated therapy rescues photoreceptors degeneration in a mouse model of retinitis pigmentosa., PMID:39693439
Phenotypic and Genetic Spectrum in 309 Consecutive Pediatric Patients with Inherited Retinal Disease., PMID:39596324
In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice., PMID:39556729
Loss of paired immunoglobin-like type 2 receptor B gene associated with age-related macular degeneration impairs photoreceptor function in mouse retina., PMID:39532089
AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis., PMID:39359097
Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutation., PMID:39333705
Analysis of PDE6G mutations in a patient with retinitis pigmentosa., PMID:39160471
CD44 signaling in Müller cells impacts photoreceptor function and survival in healthy and diseased retinas., PMID:39095775
Metabolic plasticity in a Pde6bSTOP/STOP retinitis pigmentosa mouse model following rescue., PMID:39032643
A New Mouse Model for Usher Syndrome Crossing Kunming Mice with CBA/J Mice., PMID:38754567
Cognitive decline, Aβ pathology, and blood-brain barrier function in aged 5xFAD mice., PMID:38532486
Genetics, Clinical Characteristics, and Natural History of PDE6B-Associated Retinal Dystrophy., PMID:38364953
Establishment and visual analysis of CBA/J-Pde6bY347Y/Y347X and C3H/HeJ-Pde6bY347Y/Y347X mice., PMID:38171880
The m6A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B., PMID:38157933
Identification and Characterization of Retinitis Pigmentosa in a Novel Mouse Model Caused by PDE6B-T592I., PMID:38137394
Morphological and Functional Comparison of Mice Models for Retinitis Pigmentosa., PMID:37440058
Next-generation sequencing--based genetic testing and phenotype correlation in retinitis pigmentosa patients from India., PMID:37322672
Identification of hub genes correlated with diabetic retinopathy via bioinformatics methods., PMID:37318461
Microglial and macroglial dynamics in a model of retinitis pigmentosa., PMID:37295269
A Novel Intronic Deletion in PDE6B Causes Autosomal Recessive Retinitis Pigmentosa by Interfering with RNA Splicing., PMID:37094557
Early Alterations of RNA Binding Protein (RBP) Homeostasis and ER Stress-Mediated Autophagy Contributes to Progressive Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa (RP)., PMID:37048167
A novel homozygous missense substitution p.Thr313Ile in the PDE6B gene underlies autosomal recessive retinitis pigmentosa in a consanguineous Pakistani family., PMID:36959549
Characterizing the genotypic spectrum of retinitis pigmentosa in East Asian populations: a systematic review., PMID:36856324
Inhibition of the MAPK/c-Jun-EGR1 Pathway Decreases Photoreceptor Cell Death in the rd1 Mouse Model for Inherited Retinal Degeneration., PMID:36498926
Identification of a novel large multigene deletion and a frameshift indel in PDE6B as the underlying cause of early-onset recessive rod-cone degeneration., PMID:36376065
Characterization of a novel Pde6b-deficient rat model of retinal degeneration and treatment with adeno-associated virus (AAV) gene therapy., PMID:36175490
Organotypic Retinal Explant Cultures from Macaque Monkey., PMID:36094256
A comprehensive atlas of Aggrecan, Versican, Neurocan and Phosphacan expression across time in wildtype retina and in retinal degeneration., PMID:35508614
Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity., PMID:35327647
Genetic analysis of patients with nonsyndromic and syndromic retinitis pigmentosa in Puerto Rico: a genetic legacy., PMID:35318874
Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6b+Tyrc-chFmr1tm1Cgr/J., PMID:35290907
Inherited retinal dystrophies in a Kuwaiti tribe., PMID:35272565
Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model., PMID:35195763
Exogenous PDE5 Expression Rescues Photoreceptors in RD1 Mice., PMID:35170405
Novel variants in PDE6A and PDE6B genes and its phenotypes in patients with retinitis pigmentosa in Chinese families., PMID:35033039
Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa., PMID:34916446
Viral Transduction of Human Rod Opsin or Channelrhodopsin Variants to Mouse ON Bipolar Cells Does Not Impact Retinal Anatomy or Cause Measurable Death in the Targeted Cells., PMID:34884916
Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy., PMID:34768944
PDE6B Mutation-associated Inherited Retinal Disease., PMID:34584050
Tlr2 Gene Deletion Delays Retinal Degeneration in Two Genetically Distinct Mouse Models of Retinitis Pigmentosa., PMID:34360582
Knockout of CaV1.3 L-type calcium channels in a mouse model of retinitis pigmentosa., PMID:34312410
For research use only. Not for human or drug use.
