Catalog No.
YHB52101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg171
Predicted molecular weight
21.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95057
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Distinct subgroup of the Ras family member 1, RIG, GBTS1, Rig, DIRAS1, GTP-binding protein Di-Ras1, Small GTP-binding tumor suppressor 1, Ras-related inhibitor of cell growth
M6A modification regulates tumor suppressor DIRAS1 expression in cervical cancer cells., PMID:38372700
Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease., PMID:37149695
GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS., PMID:37059183
Analysis of the function and mechanism of DIRAS1 in osteosarcoma., PMID:35413492
LINC00261 Inhibits Esophageal Cancer Radioresistance by Down-Regulating microRNA-552-3p and Promoting DIRAS1., PMID:34803403
Di-Ras2 promotes renal cell carcinoma formation by activating the mitogen-activated protein kinase pathway in the absence of von Hippel-Lindau protein., PMID:32161311
The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases., PMID:31197034
The mechanisms of DIRAS family members in role of tumor suppressor., PMID:30317588
Progression Rate Associated Peripheral Blood Biomarkers of Parkinson's Disease., PMID:29936662
Sodium butyrate induces cell death by autophagy and reactivates a tumor suppressor gene DIRAS1 in renal cell carcinoma cell line UOK146., PMID:29556894
RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells., PMID:29368982
Absence Seizures as a Feature of Juvenile Myoclonic Epilepsy in Rhodesian Ridgeback Dogs., PMID:29194766
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression., PMID:28806394
Methylation of DIRAS1 promotes colorectal cancer progression and may serve as a marker for poor prognosis., PMID:28491151
Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1., PMID:28223533
The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases., PMID:26814130
Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway., PMID:26635085
Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides., PMID:26149690
Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma., PMID:23436800
DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders., PMID:21750579
GTPase activity of Di-Ras proteins is stimulated by Rap1GAP proteins., PMID:21686267
A genome-wide Ras-effector interaction network., PMID:17544445
Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties., PMID:12194967
Rig is a novel Ras-related protein and potential neural tumor suppressor., PMID:12107278
Identification of a novel gene product, RIG, that is down-regulated in human glioblastoma., PMID:9070656
For research use only. Not for human or drug use.
