Catalog No.
YHK79401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly524-Leu713
Predicted molecular weight
24.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UL51
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HCN2, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, BCNG-2, Brain cyclic nucleotide-gated channel 2, BCNG2
ZD7288 ameliorates long-term cerebral ischemia reperfusion-induced deterioration of spatial memory by regulating the expressions of NMDA receptor subunits in rats., PMID:40415080
MiR-1 alleviates chronic heart failure through HCN2/HCN4 axis in vitro., PMID:40252568
Fibroblast growth factor 22., PMID:40139106
A Novel Oxo-Palmatine Derivative 2q as Potent Reversal Agents Against Alzheimer's Disease., PMID:40079275
Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC., PMID:40053590
HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer's disease., PMID:40016780
Chlordecone reduces hyperpolarization-activated-current (Ih) conductance in honeybee., PMID:39983853
Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety., PMID:39914775
An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila., PMID:39823301
PGE2 and HCN2 ion channels are critical mediators of pain initiated by angiotensin II., PMID:39736364
Spinal Nerve Axotomy: Effects on Ih In Vivo and HCNs in DRG Neurons., PMID:39684600
Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells., PMID:39663000
Interleukin-6 Modulates the Expression and Function of HCN Channels: A Link Between Inflammation and Atrial Electrogenesis., PMID:39596280
Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle., PMID:39584396
Sensory neuroimmune signaling in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis., PMID:39481654
Analysis of epilepsy-associated variants in HCN3 - Functional implications and clinical observations., PMID:39361439
Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome., PMID:39344832
Upregulation of HCN2 in ventral tegmental area is involved in morphine-induced conditioned place preference in rats., PMID:39267158
Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation., PMID:39223673
Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner., PMID:39075089
Thyroid Hormone Receptors in Control of Heart Rate., PMID:39047059
Multiple Exposures to Sevoflurane General Anesthesia During Pregnancy Inhibit CaMKII/CREB Axis by Downregulating HCN2 to Induce an Autism-Like Phenotype in Offspring Mice., PMID:39017898
HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice., PMID:38961317
Structural determinants of ivabradine block of the open pore of HCN4., PMID:38917012
High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons., PMID:38891076
Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice., PMID:38757582
Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice., PMID:38670100
LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction., PMID:38652113
Partial Resistance to Thyroid Hormone-Induced Tachycardia and Cardiac Hypertrophy in Mice Lacking Thyroid Hormone Receptor β., PMID:38526409
cAMP binding to closed pacemaker ion channels is cooperative., PMID:38377199
Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice., PMID:38353058
The role of HCN channels on the effects of T-type calcium channels and GABAA receptors in the absence epilepsy model of WAG/Rij rats., PMID:38159130
Opioid-Induced Hyperalgesia and Tolerance Are Driven by HCN Ion Channels., PMID:38124021
Smurf2-Mediated Ubiquitination of FOXO4 Regulates Oxygen-glucose Deprivation/Reperfusion-induced Pyroptosis of Cortical Neurons., PMID:37861000
HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice., PMID:37762124
A novel de novo HCN2 loss-of-function variant causing developmental and epileptic encephalopathy treated with a ketogenic diet., PMID:37746765
Anti-inflammatory, Anti-fibrotic and Pro-cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR-1 and miR-199a on Human Cardiac Fibroblasts., PMID:37700183
LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction., PMID:37693562
Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons., PMID:37558490
Investigation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in vitro inflammation model at molecular level., PMID:37432633
Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes., PMID:37408215
Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling., PMID:37306715
Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity., PMID:37298834
Resistance to thyroid hormone induced tachycardia in RTHα syndrome., PMID:37286550
Xenon's Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice., PMID:37239964
Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function., PMID:37217978
Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model., PMID:37085778
Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry., PMID:37068253
HCN channels and absence seizures., PMID:37001612
Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels., PMID:36890518
For research use only. Not for human or drug use.
