Catalog No.
YHK79301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val199
Predicted molecular weight
24.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7LBR1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHMP1b, C18orf2, CHMP1B, hVps46-2, Vps46-2, Charged multivesicular body protein 1b, CHMP1.5, Chromatin-modifying protein 1b, Vacuolar protein sorting-associated protein 46-2
Microscale Proteomic Analysis of the Endolymphatic Sac in Menière's Disease Patients., PMID:40062362
Corneal stromal cells from patients with keratoconus exhibit alterations in the ESCRT-dependent machinery responsible for multivesicular body formation., PMID:39890050
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation., PMID:38635626
Selective cargo sorting in stem cell-derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration., PMID:38037469
IST1 regulates select recycling pathways., PMID:37926552
IST1 regulates select endosomal recycling pathways., PMID:37577466
Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation., PMID:36872252
Isolation and proteomic profiling of urinary exosomes from patients with colorectal cancer., PMID:36759883
Brominated lipid probes expose structural asymmetries in constricted membranes., PMID:36624348
Asgard ESCRT-III and VPS4 reveal conserved chromatin binding properties of the ESCRT machinery., PMID:36221007
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B., PMID:35995394
Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1., PMID:35858336
Hepatitis C Virus-Induced ROS/JNK Signaling Pathway Activates the E3 Ubiquitin Ligase Itch to Promote the Release of HCV Particles via Polyubiquitylation of VPS4A., PMID:35044214
Impact of the Endosomal Escape Activity of Cell-Penetrating Peptides on the Endocytic Pathway., PMID:32786263
Membrane constriction and thinning by sequential ESCRT-III polymerization., PMID:32251413
The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking., PMID:32175818
Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function., PMID:31787869
Structural Insights into AQP2 Targeting to Multivesicular Bodies., PMID:31661793
ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic., PMID:31587092
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III., PMID:31227594
iTRAQ-based quantitative proteomics analysis of the spleen reveals innate immunity and cell death pathways associated with heat stress in broilers (Gallus gallus)., PMID:30664952
CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis., PMID:29933386
Quantitative Proteomics Identify the Possible Tumor Suppressive Role of Protease-Activated Receptor-4 in Esophageal Squamous Cell Carcinoma Cells., PMID:29502225
Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis., PMID:27497741
Structure and membrane remodeling activity of ESCRT-III helical polymers., PMID:26634441
A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression., PMID:26282201
Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains., PMID:25657007
The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis., PMID:25649438
A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5., PMID:25637630
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport., PMID:23105106
"Orphan" retrogenes in the human genome., PMID:23066043
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis., PMID:23015756
Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1., PMID:21616915
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses., PMID:20824097
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition., PMID:20805225
Structural basis for ESCRT-III protein autoinhibition., PMID:19525971
The ESCRT-related CHMP1A and B proteins mediate multivesicular body sorting of auxin carriers in Arabidopsis and are required for plant development., PMID:19304934
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B., PMID:18997780
Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly., PMID:18385515
Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments., PMID:18316332
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation., PMID:17711858
Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo., PMID:16760479
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A., PMID:16174732
The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B., PMID:15537668
For research use only. Not for human or drug use.
