Catalog No.
YHK79201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln31-Val222
Predicted molecular weight
23.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BUX1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Cation transport regulator-like protein 1, CHAC1, Botch, BOTCH, Blocks Notch protein
O-Desmethyltramadol Enhanced Anti-Cancer Efficacy over Tramadol Through Non-μ-Opioid Receptor and Differential Cellular Contexts of Human Breast Cancer Cells., PMID:40362379
Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion., PMID:40354766
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis., PMID:40267214
Paliperidone Inhibits Ferroptosis Mediated by Autophagy in Renal Tubular Epithelial Cells by Targeting CHAC1., PMID:40259582
Chlamydia pneumoniae relies on host glutathione for its growth and induces integrated stress response-mediated changes in macrophage glutathione metabolism., PMID:40187637
Icariside II induces ferroptosis through the down-regulation of SLC7A11 in ovarian cancer., PMID:40186304
Vitamin D3 and its active form calcitriol suppress erythroleukemia through upregulation of CHAC1 and downregulation of NOTCH1., PMID:40146328
Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis., PMID:40037075
Febuxostat therapy improved the outcomes of cardiorenal syndrome rodent through alleviating xanthine oxidase-induced oxidative stress and mitochondrial dysfunction., PMID:39990671
Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc-/GPX4 pathway., PMID:39944356
Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation., PMID:39893168
TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis., PMID:39838504
CHAC1 Mediates Endoplasmic Reticulum Stress-Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation., PMID:39836526
Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway., PMID:39819316
Downregulation of the SREBP pathways and disruption of redox status by 25-hydroxycholesterol predispose cells to ferroptosis., PMID:39778605
Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement., PMID:39667319
Compound Bacillus improves eggshell quality and egg metabolites of hens by promoting the metabolism balance of calcium and phosphorus and uterine cell proliferation., PMID:39640545
Identification of Biomarkers and Molecular Pathways Implicated in Smoking and COVID-19 Associated Lung Cancer Using Bioinformatics and Machine Learning Approaches., PMID:39595659
CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers., PMID:39534397
Research on the Therapeutic Effect of Qizhu Anti Cancer Recipe on Colorectal Cancer Based on RNA Sequencing Analysis., PMID:39501961
The Involvement of Endoplasmic Reticulum Stress during the Interaction between Calcium Oxalate Crystals and Renal Tubular Epithelial Cells., PMID:39452083
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability., PMID:39433724
CREBRF regulates apoptosis and estradiol via ISG15/ISGylation in pig granulosa cells., PMID:39419455
Protein folding dependence on selenoprotein M contributes to steady cartilage extracellular matrix repressing ferroptosis via PERK/ATF4/CHAC1 axis., PMID:39419437
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation., PMID:39368995
Prognostic Values of Ferroptosis-Related Proteins ACSL4, SLC7A11, and CHAC1 in Cholangiocarcinoma., PMID:39335604
Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway., PMID:39258755
Whole transcriptome sequencing indicated the Anti-tumor immunity of NLRP3 in breast cancer., PMID:39214479
Identification and validation of ferroptosis related markers in erythrocyte differentiation of umbilical cord blood-derived CD34+ cell by bioinformatic analysis., PMID:39139819
Caffeic Acid Reduces Ferroptosis to Dampen Inflammation of Keratinocytes in Psoriasis by Inhibiting EGR1-induced Transcription Activation of CHAC1., PMID:39129295
Potential Roles of Long Non-coding RNAs in the Pathogenesis of Periodontitis: Inflammation Response, Immune Infiltration, Collagen Fibers Synthesis, and Bone Remodeling., PMID:39108010
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity., PMID:38942747
Abnormal epigenetic memory of mesenchymal stem and progenitor cells caused by fetal malnutrition induces hypertension and renal injury in adulthood., PMID:38926588
Glutathione‑degrading enzymes in the complex landscape of tumors (Review)., PMID:38847236
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis., PMID:38822984
Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer., PMID:38769193
Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC., PMID:38762605
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis., PMID:38681208
Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway., PMID:38670420
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway., PMID:38663476
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation., PMID:38516826
ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis., PMID:38499213
Establishment of Golgi apparatus-related genes signature to predict the prognosis and immunotherapy response in gastric cancer patients., PMID:38489711
ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma., PMID:38393971
Doxorubicin loaded octacalcium phosphate particles as controlled release drug delivery systems: Physico-chemical characterization, in vitro drug release and evaluation of cell death pathway., PMID:38387818
ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling., PMID:38287795
Decoding the genetic landscape of allergic rhinitis: a comprehensive network analysis revealing key genes and potential therapeutic targets., PMID:38266128
CHAC1 promotes cell ferroptosis and enhances radiation sensitivity in thyroid carcinoma., PMID:38247333
Tremella fuciformis polysaccharides induce ferroptosis in Epstein-Barr virus-associated gastric cancer by inactivating NRF2/HO-1 signaling., PMID:38244583
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway., PMID:38043156
For research use only. Not for human or drug use.
