Catalog No.
YHH30201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu110-Glu386
Predicted molecular weight
33.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16584
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTK1, MLK3, SPRK, MAP3K11, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase
Mixed lineage kinase (MLK) controls tumor development and angiogenesis., PMID:40314847
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance., PMID:39901302
Marine Staurosporine Analogues: Activity and Target Identification in Triple-Negative Breast Cancer., PMID:39452867
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes., PMID:38909044
Multi-Omic Analysis Reveals Genetic Determinants and Therapeutic Targets of Chronic Kidney Disease and Kidney Function., PMID:38892221
Circ_002033 Regulates Proliferation, Apoptosis, and Oxidative Damage of Bovine Mammary Epithelial Cells via the miR-199a-5p-MAP3K11 Axis in Heat Stress., PMID:38869955
MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFβ pathway., PMID:38858590
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout., PMID:38831441
Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway., PMID:38663526
Construction and experimental validation of a novel ferroptosis-related gene signature for myelodysplastic syndromes., PMID:38578040
Identification of the transcriptome signatures and immune-inflammatory responses in postmenopausal osteoporosis., PMID:38187229
Identification of immune-related genes in diagnosing atherosclerosis with rheumatoid arthritis through bioinformatics analysis and machine learning., PMID:36969166
Tacrolimus in the treatment of childhood nephrotic syndrome: Machine learning detects novel biomarkers and predicts efficacy., PMID:36521865
MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma., PMID:36103355
Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function., PMID:35867711
Mechanisms underlying melanoma invasion as a consequence of MLK3 loss., PMID:35307409
Circular RNA ACTA1 Acts as a Sponge for miR-199a-5p and miR-433 to Regulate Bovine Myoblast Development through the MAP3K11/MAP2K7/JNK Pathway., PMID:35234473
Elevated expression of RIT1 hyperactivates RAS/MAPK signal and sensitizes hepatocellular carcinoma to combined treatment with sorafenib and AKT inhibitor., PMID:34845378
MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium., PMID:32867783
Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells., PMID:32759234
Kinases: Understanding Their Role in HIV Infection., PMID:32257606
Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression., PMID:32235890
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity., PMID:32209667
Suppression of lymphocyte apoptosis in spleen by CXCL13 after porcine circovirus type 2 infection and regulatory mechanism of CXCL13 expression in pigs., PMID:30819249
Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus-A Co-expression Network Based Analysis., PMID:30627105
Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3., PMID:29980598
A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy., PMID:29506515
A novel lnc-PCF promotes the proliferation of TGF-β1-activated epithelial cells by targeting miR-344a-5p to regulate map3k11 in pulmonary fibrosis., PMID:29072702
Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis., PMID:28388540
Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation., PMID:27613090
Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11)., PMID:26717044
Mechanisms of stem cell osteogenic differentiation on TiO2 nanotubes., PMID:26520050
Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response., PMID:26485378
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells., PMID:26138442
Emergence of structure through protein-protein interactions and pH changes in dually predicted coiled-coil and disordered regions of centrosomal proteins., PMID:25091198
MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species., PMID:24894995
MAP kinase genes and colon and rectal cancer., PMID:23027623
Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen., PMID:22761715
miR-93 suppresses proliferation and colony formation of human colon cancer stem cells., PMID:22180714
Effects of SMYD3 over-expression on cell cycle acceleration and cell proliferation in MDA-MB-231 human breast cancer cells., PMID:20957523
Effects of SMYD3 overexpression on transformation, serum dependence, and apoptosis sensitivity in NIH3T3 cells., PMID:19472189
Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail., PMID:18502891
Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm., PMID:17377140
Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening., PMID:17257639
Genomic sequencing reveals the structure of the Kcnk6 and map3k11 genes and their close vicinity to the sipa1 gene on mouse chromosome 19., PMID:10894943
For research use only. Not for human or drug use.
