Catalog No.
YHK78501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser130
Predicted molecular weight
17.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NXR8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p47ING3, ING3, Inhibitor of growth protein 3
Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers., PMID:40149370
Decreased Nuclear Immunoexpression of ING3 is a Frequent Event in Lip Carcinogenesis., PMID:39412571
Bone health index in the assessment of bone health: The Generation R Study., PMID:38460828
ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling., PMID:38281617
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3., PMID:37279970
Structural analysis of ING3 protein and histone H3 binding., PMID:37148949
Landscape of co-expressed genes between the myocardium and blood in sepsis and ceRNA network construction: a bioinformatic approach., PMID:37069215
Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus., PMID:36943599
A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency., PMID:36706161
Newly identified tumor suppressor functions of ING proteins., PMID:36521226
Expanding the molecular spectrum of gene fusions in endometrial stromal sarcoma: Novel subunits of the chromatin remodeling complexes PRC2 and NuA4/TIP60 as alternative fusion partners., PMID:36445224
Long Noncoding RNA LINC01554 Inhibits the Progression of NSCLC Progression by Functioning as a ceRNA for miR-1267 and Regulating ING3/Akt/mTOR Pathway., PMID:35845928
Inhibitor of Growth Factors Regulate Cellular Senescence., PMID:35804879
Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation., PMID:34791430
ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions., PMID:34787253
ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer., PMID:34685579
A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells., PMID:34439818
Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target., PMID:34315984
Overexpression of ING3 is associated with attenuation of migration and invasion in breast cancer., PMID:34007308
Nuclear ING3 Expression Is Correlated With a Good Prognosis of Breast Cancer., PMID:33469513
Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis., PMID:32334834
Genomic profiling of BCOR-rearranged uterine sarcomas reveals novel gene fusion partners, frequent CDK4 amplification and CDKN2A loss., PMID:32156473
Loss of Ing3 Expression Results in Growth Retardation and Embryonic Death., PMID:31905726
Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC)., PMID:31886514
Focus-ING on DNA Integrity: Implication of ING Proteins in Cell Cycle Regulation and DNA Repair Modulation., PMID:31878273
Biological Functions of the ING Proteins., PMID:31752342
Integrative analysis of mRNA-miRNA-TFs reveals the key regulatory connections involved in basal cell carcinoma., PMID:31641848
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density., PMID:30890710
Overexpression of miR-101-2 in donor cells improves the early development of Holstein cow somatic cell nuclear transfer embryos., PMID:30879805
ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks., PMID:30804473
Inhibitor of growth 3 induces cell death by regulating cell proliferation, apoptosis and cell cycle arrest by blocking the PI3K/AKT pathway., PMID:29855536
Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein., PMID:29381681
ING3 promotes prostate cancer growth by activating the androgen receptor., PMID:28511652
Immunohistochemical profile of ING3 protein in normal and cancerous tissues., PMID:28454301
Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression., PMID:28403887
Propofol inhibits the growth and survival of gastric cancer cells in vitro through the upregulation of ING3., PMID:27840947
INGs are potential drug targets for cancer., PMID:27544390
Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3., PMID:27281824
ING3 is associated with increased cell invasion and lethal outcome in ERG-negative prostate cancer patients., PMID:26803516
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin., PMID:26095369
ING3 protein expression profiling in normal human tissues suggest its role in cellular growth and self-renewal., PMID:25819753
RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival., PMID:25189355
Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats., PMID:25156538
Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling., PMID:25151306
Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis., PMID:24927342
SUMOylation of the ING1b tumor suppressor regulates gene transcription., PMID:24903338
Molecular cloning and expression analysis of inhibitor of growth protein 3 (ING3) in the Manila clam, Ruditapes philippinarum., PMID:24566680
ING3 is essential for asymmetric cell division during mouse oocyte maturation., PMID:24066152
p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms., PMID:23608533
Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis., PMID:23458164
For research use only. Not for human or drug use.
