Catalog No.
YHK78201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp392-Thr576
Predicted molecular weight
23.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A1A4S6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Graf-related protein 2, GTPase regulator associated with focal adhesion kinase 2, ARHGAP10, GRAF2, Rho GTPase-activating protein 10, Rho-type GTPase-activating protein 10
Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration., PMID:39021083
ARHGAP10, Transcriptionally Regulated by Sodium Butyrate, Promotes Ferroptosis of Ovarian Cancer Cells., PMID:38812318
Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells., PMID:38425400
SMAD4 inhibits glycolysis in ovarian cancer through PI3K/AKT/HK2 signaling pathway by activating ARHGAP10., PMID:38230565
CircRNA ARHGAP10 promotes osteogenic differentiation through the miR-335-3p/RUNX2 pathway in aortic valve calcification., PMID:38090284
Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a Novel Drug Target., PMID:37958606
Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment., PMID:37582769
Kinetics of Arf1 inactivation regulates Golgi organisation and function in non-adherent fibroblasts., PMID:36946871
Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene., PMID:36462727
Rho GTPase-activating protein 17 (ARHGAP17) as additional autoimmune target in ARHGAP26-IgG/anti-Ca autoantibody-associated autoimmune encephalitis., PMID:36333454
Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia., PMID:35987254
Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate., PMID:35817949
Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis., PMID:35624318
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix, and vesicles., PMID:35472162
Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease., PMID:35171450
The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts., PMID:34869381
Gene Expression Analysis Provides New Insights into the Mechanism of Intramuscular Fat Formation in Japanese Black Cattle., PMID:34440281
ARHGAP10 inhibits the epithelial-mesenchymal transition of non-small cell lung cancer by inactivating PI3K/Akt/GSK3β signaling pathway., PMID:34174897
miR-769-5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells., PMID:33732308
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons., PMID:33482876
Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis., PMID:32783691
ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk., PMID:32699248
ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42., PMID:32391922
GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508., PMID:32344433
Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways., PMID:32255672
Expression of ARHGAP10 correlates with prognosis of prostate cancer., PMID:31933772
ARHGAP10 Inhibits the Proliferation and Metastasis of CRC Cells via Blocking the Activity of RhoA/AKT Signaling Pathway., PMID:31920339
miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10., PMID:31789419
CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression., PMID:31445707
Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer., PMID:31396458
The roles of ARHGAP10 in the proliferation, migration and invasion of lung cancer cells., PMID:28943961
Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation., PMID:28539409
ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells., PMID:27010858
The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts., PMID:24821726
X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3., PMID:21636067
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation., PMID:21173159
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations., PMID:20158304
A novel human protein is able to interact with hepatitis B virus core deletion mutant but not with the wild-type protein., PMID:19770013
ARF1 is directly involved in dynamin-independent endocytosis., PMID:18084285
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport., PMID:16527809
ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion., PMID:16184169
[ARHGAP10, a novel RhoGAP at the cross-road between ARF1 and Cdc42 pathways, regulates Arp2/3 complex and actin dynamics on Golgi membranes]., PMID:16115449
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics., PMID:15793564
Identification and characterization of ARHGAP27 gene in silico., PMID:15492870
Characterization of human ARHGAP10 gene in silico., PMID:15375573
A putative Xenopus Rho-GTPase activating protein (XrGAP) gene is expressed in the notochord and brain during the early embryogenesis., PMID:12711552
ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein., PMID:12056806
PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family., PMID:11432776
Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein., PMID:11238453
For research use only. Not for human or drug use.
