Catalog No.
YHG75101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp71-Asp206
Predicted molecular weight
18.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14197
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DS1, MRPL58, Immature colon carcinoma transcript 1 protein, Digestion substraction 1, Mitochondrial large ribosomal subunit protein mL62, DS-1, ICT1, MRP-L58, Peptidyl-tRNA hydrolase ICT1, mitochondrial, 39S ribosomal protein L58, mitochondrial
Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency., PMID:40452409
Comparative proteomic analysis reveals the response mechanism of freshwater leech (Whitmania pigra) under heat-stress challenge., PMID:39729945
Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors., PMID:35260756
Structural basis of translation termination, rescue, and recycling in mammalian mitochondria., PMID:33878294
ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway., PMID:33585660
Expression analysis of mammalian mitochondrial ribosomal protein genes., PMID:32987154
MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1., PMID:29951881
Clinical research on one-third dose verteporfin photodynamic therapy in the treatment of chronic central serous chorioretinopathy., PMID:29424884
Knockdown of immature colon carcinoma transcript 1 induces suppression of proliferation, S-phase arrest and apoptosis in leukemia cells., PMID:29328466
Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance., PMID:29130100
Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells., PMID:29036264
miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells., PMID:28987942
A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes., PMID:28826487
ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma., PMID:28629825
ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis., PMID:28290601
Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells., PMID:27413166
Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer., PMID:27411551
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria., PMID:27029019
Immature Colon Carcinoma Transcript 1 Is Essential for Prostate Cancer Cell Viability and Proliferation., PMID:26186090
Ribosome rescue and translation termination at non-standard stop codons by ICT1 in mammalian mitochondria., PMID:25233460
Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ., PMID:24322300
Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome., PMID:23908630
Solution structure of the catalytic domain of the mitochondrial protein ICT1 that is essential for cell vitality., PMID:20869366
ICT1 comes to the rescue of mitochondrial ribosomes., PMID:20234387
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome., PMID:20186120
Expression of differentiation-related genes in colorectal cancer: possible implications for prognosis., PMID:9810514
Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation., PMID:8575443
For research use only. Not for human or drug use.
