Catalog No.
YHK77801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser21-Arg232
Predicted molecular weight
26.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86X24
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cancer/testis antigen 46, CT46, HORMA domain-containing protein 1, NOHMA, Newborn ovary HORMA protein, HORMAD1
CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve., PMID:40488668
Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination., PMID:40050306
The Germline-Restricted Chromosome of Male Zebra Finches in Meiotic Prophase I: A Proteinaceous Scaffold and Chromatin Modifications., PMID:39595299
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice., PMID:39511641
TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis., PMID:39207914
Differential phosphorylation of two serine clusters in mouse HORMAD1 during meiotic prophase I progression., PMID:38897409
Principles of chromosome organization for meiotic recombination., PMID:38657614
RETRACTED: Identification of potential therapeutic targets for breast cancer using Mendelian randomization analysis and drug target prediction., PMID:38581229
Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes., PMID:38580643
The N-terminal modification of HORMAD2 causes its ectopic persistence on synapsed chromosomes without meiotic blockade., PMID:38401263
Expression of HORMAD1 in Chronic Rhinosinusitis and Its Correlation with Inflammatory Factors., PMID:38185961
Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes., PMID:38077023
The cancer testes antigen, HORMAD1, limits genomic instability in cancer cells by protecting stalled replication forks., PMID:37838177
TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis., PMID:37808842
Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins., PMID:37794593
Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas., PMID:37371097
HORMAD1 overexpression predicts response to anthracycline-cyclophosphamide and survival in triple-negative breast cancers., PMID:36852691
A biallelic loss of function variant in HORMAD1 within a large consanguineous Turkish family is associated with spermatogenic arrest., PMID:36524333
A maternal high-fat diet induces fetal origins of NASH-HCC in mice., PMID:35907977
FBXW24 controls female meiotic prophase progression by regulating SYCP3 ubiquitination., PMID:35858239
Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure., PMID:35857787
Role of GBP1 in innate immunity and potential as a tuberculosis biomarker., PMID:35773466
Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance., PMID:35768547
SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination., PMID:35489071
[Corrigendum] HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance., PMID:34296290
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance., PMID:34036395
Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes., PMID:33842489
Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment., PMID:33238277
Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase., PMID:32931493
COMET Functions as a PCH2 Cofactor in Regulating the HORMA Domain Protein ASY1., PMID:32857973
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells., PMID:32647118
State changes of the HORMA protein ASY1 are mediated by an interplay between its closure motif and PCH2., PMID:32558910
Ensuring meiotic DNA break formation in the mouse pseudoautosomal region., PMID:32461690
Licensing meiotic progression†., PMID:32338765
Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy., PMID:31444302
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains., PMID:31237565
Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes., PMID:30853435
Increased Risk of Inflammatory Bowel Disease in Families with Tonsillectomy: A Danish National Cohort Study., PMID:30461527
The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells., PMID:30333500
Impeding DNA Break Repair Enables Oocyte Quality Control., PMID:30270110
HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress., PMID:30185546
Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1., PMID:29414051
The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure., PMID:28844861
The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding., PMID:28659378
A strategy to apply quantitative epistasis analysis on developmental traits., PMID:28506208
RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary., PMID:28364521
Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis., PMID:28342926
Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice., PMID:27723721
Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models., PMID:27739607
An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells., PMID:26923702
For research use only. Not for human or drug use.
