Catalog No.
YHB37601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala726-Leu853
Predicted molecular weight
16.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75969
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fibrousheathin I, AKAP110, CT82, Fibrous sheath protein of 95 kDa, FSP95, Fibrousheathin-1, A-kinase anchor protein 110 kDa, AKAP3, Protein kinase A-anchoring protein 3, Cancer/testis antigen 82, AKAP 110, AKAP-3, Sperm oocyte-binding protein, SOB1, A-kinase anchor protein 3, PRKA3
BDE-209 toxicity: From spermiogenesis to sexual maturity in F1 male mice., PMID:40311472
Loss of Cep135 causes oligoasthenoteratozoospermia and male infertility in mice., PMID:40095067
Core N-DRC components play a crucial role in embryonic development and postnatal organ development., PMID:40089458
Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses., PMID:39972276
The testis-specific gene 1700030J22Rikis essential for sperm flagellar function and male fertility in mice., PMID:39710003
CABS1 Is Essential for Progressive Motility and the Integrity of Fibrous Sheath in Mouse Epididymal Spermatozoa., PMID:39526486
Quantitative phosphoproteomics explain cryopreservation-induced reductions in ram sperm motility., PMID:38438079
Evaluation of The 1499T>C Variant in The AKAP3 Gene of Infertile Men with Multiple Morphological Abnormalities of The Sperm Flagella Phenotype: A Case-Control Study., PMID:38368523
AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertility†., PMID:38145487
Experimental and molecular support for Cfap70 as a causative gene of 'multiple morphological abnormalities of the flagella' with male infertility†., PMID:37458246
STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis., PMID:37146716
Identification of protein candidates in spermatozoa of water buffalo (Bubalus bubalis) bulls helps in predicting their fertility status., PMID:36891514
DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath., PMID:36792588
Phosphoproteomics for the identification of new mechanisms of cryodamage: the role of SPATA18 in the control of stallion sperm function†., PMID:36468681
Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens)., PMID:36277216
MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway., PMID:36267566
Inhibition of 26S proteasome enhances AKAP3-mediated cAMP-PKA signaling during boar sperm capacitation., PMID:36209601
Comparative Proteomic Analyses of Poorly Motile Swamp Buffalo Spermatozoa Reveal Low Energy Metabolism and Deficiencies in Motility-Related Proteins., PMID:35804605
The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency., PMID:35663320
The cancer-testis antigen a-kinase anchor protein 3 facilitates breast cancer progression via activation of the PTEN/PI3K/AKT/mTOR signaling., PMID:35322748
Structural modeling of human AKAP3 protein and in silico analysis of single nucleotide polymorphisms associated with sperm motility., PMID:35256641
Homozygous variants in AKAP3 induce asthenoteratozoospermia and male infertility., PMID:35228300
Protein Kinase A (PRKA) Activity Is Regulated by the Proteasome at the Onset of Human Sperm Capacitation., PMID:34944009
Protein Identification of Spermatozoa and Seminal Plasma in Bottlenose Dolphin (Tursiops truncatus)., PMID:34336830
Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa., PMID:34336820
Prediction of 3D Protein Structure Based on The Mutation of AKAP3 and PLOD3 Genes in The Case of Non-Obstructive Azoospermia., PMID:32681621
Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice., PMID:32460071
[Role of outer dense fiber in multiple morphological abnormalities of the sperm flagella in Akap4 gene defect mice]., PMID:31969501
Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility., PMID:31969357
Fluoride exposure alters the ultra-structure of sperm flagellum via reducing key protein expressions in testis., PMID:31901658
Retinoic acid and/or progesterone differentiate mouse induced pluripotent stem cells into male germ cells in vitro., PMID:31646671
Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding., PMID:31254143
Insight on multiple morphological abnormalities of sperm flagella in male infertility: what is new?, PMID:31210147
Differential expression of TLRs and AKAP3 in cigarette smoked mice testis., PMID:31074059
Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella., PMID:30683861
Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification., PMID:27857155
Re: AKAP3 Degradation in Sperm Capacitation is Regulated by its Tyrosine Phosphorylation., PMID:27186783
Regulation of Sperm Capacitation by the 26S Proteasome: An Emerging New Paradigm in Spermatology., PMID:27053366
AKAP3 correlates with triple negative status and disease free survival in breast cancer., PMID:26458542
AKAP3 degradation in sperm capacitation is regulated by its tyrosine phosphorylation., PMID:26093290
Interactome of the negative regulator of nuclear import BRCA1-binding protein 2., PMID:25820252
Morphological characteristics and initial genetic study of multiple morphological anomalies of the flagella in China., PMID:25652624
Sperm-specific AKAP3 is a dual-specificity anchoring protein that interacts with both protein kinase a regulatory subunits via conserved N-terminal amphipathic peptides., PMID:24687590
AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis., PMID:24648398
[Molecular genetic mechanisms of teratozoospermia]., PMID:24432614
Identification of differentially expressed proteins in fresh and frozen-thawed boar spermatozoa by iTRAQ-coupled 2D LC-MS/MS., PMID:24357664
Dissociation between AKAP3 and PKARII promotes AKAP3 degradation in sperm capacitation., PMID:23894359
Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity., PMID:23303679
Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity., PMID:23151147
Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma., PMID:22941507
For research use only. Not for human or drug use.
