Catalog No.
YHG37401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser12-Lys248
Predicted molecular weight
29.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13017
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Rho-type GTPase-activating protein 5, ARHGAP5, RHOGAP5, p190-B, Rho GTPase-activating protein 5
miR-1225-3p regulates fibrosis in mesangial cells via SMURF2-mediated ubiquitination of ChREBP in diabetic kidney disease., PMID:40211762
Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells., PMID:39756968
ZFHX2-AS1 interacts with DKC1 to regulate ARHGAP5 pseudouridylation and suppress ovarian cancer progression., PMID:39368791
Exposure to BaA inhibits trophoblast cell invasion and induces miscarriage by regulating the DEC1/ARHGAP5 axis and promoting ubiquitination-mediated degradation of MMP2., PMID:39191013
Integrated analysis identified the role of three family members of ARHGAP in pancreatic adenocarcinoma., PMID:38783033
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats., PMID:37946400
Multiancestry genomic and transcriptomic analysis of gastric cancer., PMID:36914835
Conserved microRNAs and Flipons Shape Gene Expression during Development by Altering Promoter Conformations., PMID:36902315
Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis., PMID:36790698
Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1., PMID:36632741
A prognostic risk prediction model based on ferroptosis-related long non-coding RNAs in bladder cancer: A bulk RNA-seq research and scRNA-seq validation., PMID:36595859
N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma., PMID:36354136
The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay., PMID:36178483
RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis., PMID:36077054
A novel intergenic region ALK fusion is targetable by alectinib in a non-small cell lung cancer patient with brain metastasis., PMID:35946559
Prognostic values of the immune microenvironment-related non-coding RNA IGF2BP2-AS1 in bladder cancer., PMID:35894701
miRNA-Gene Interaction Network Construction Strategy to Discern Promising Traditional Chinese Medicine against Osteoporosis., PMID:35757478
Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling., PMID:35726387
miR-486-5p inhibits invasion and migration of HTR8/SVneo trophoblast cells by down-regulating ARHGAP5., PMID:35477045
Identification of Candidate lncRNA and Pseudogene Biomarkers Associated with Carbon-Nanotube-Induced Malignant Transformation of Lung Cells and Prediction of Potential Preventive Drugs., PMID:35270630
Exosomes derived from human umbilical cord mesenchymal stem cells reduce tendon injuries via the miR-27b-3p/ARHGAP5/RhoA signaling pathway., PMID:35130628
Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p., PMID:34986849
Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein., PMID:34370213
High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis., PMID:34285193
Epilepsy-Associated UBE3A Deficiency Downregulates Retinoic Acid Signalling Pathway., PMID:33995501
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis., PMID:32705204
Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling., PMID:32663194
Identification of the key genes and microRNAs in adult acute myeloid leukemia with FLT3 mutation by bioinformatics analysis., PMID:32547322
Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis., PMID:32483433
Meningitic Escherichia coli Induction of ANGPTL4 in Brain Microvascular Endothelial Cells Contributes to Blood-Brain Barrier Disruption via ARHGAP5/RhoA/MYL5 Signaling Cascade., PMID:31766605
Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer., PMID:31097692
p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease., PMID:31013840
PseudoGTPase domains in p190RhoGAP proteins: a mini-review., PMID:30514771
Lactic acid induced microRNA-744 enhances motility of SiHa cervical cancer cells through targeting ARHGAP5., PMID:30423314
SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression., PMID:30250020
The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase., PMID:30174148
Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility., PMID:29979793
p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity., PMID:29934311
Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models., PMID:29545725
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome., PMID:29097442
p190RhoGAP proteins contain pseudoGTPase domains., PMID:28894085
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation., PMID:28176763
Polygenic Control of Carotid Atherosclerosis in a BALB/cJ × SM/J Intercross and a Combined Cross Involving Multiple Mouse Strains., PMID:28040783
VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells., PMID:27231093
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions., PMID:26368311
MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5., PMID:25961434
Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility., PMID:24759231
miR-20a promotes prostate cancer invasion and migration through targeting ABL2., PMID:24464651
Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B rhoGAP., PMID:24316134
Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell lines., PMID:24040438
For research use only. Not for human or drug use.
