Catalog No.
YHK77301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys146-Asn276
Predicted molecular weight
17.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6N1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
COX11, Cytochrome c oxidase assembly protein COX11, mitochondrial
Cytochrome c oxidase inactivation in Physcomitrium patens reveals that respiration coordinates plant metabolism., PMID:40324757
Targeting PTBP3-Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis., PMID:40270362
Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5., PMID:40051915
Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics., PMID:39901036
Roles of Copper Transport Systems Members in Breast Cancer., PMID:39676279
Transcription factor AtNAC002 positively regulates Cu toxicity tolerance in Arabidopsis thaliana., PMID:39442300
Structural variations of a new fertility restorer gene, Rf20, underlie the restoration of wild abortive-type cytoplasmic male sterility in rice., PMID:38956872
LncRNA FGD5-AS1 Alleviates Inflammation in Allergic Rhinitis through the miR-223-3p/COX11 Axis., PMID:38071964
Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae., PMID:38068960
Sepsis induced cardiotoxicity by promoting cardiomyocyte cuproptosis., PMID:38006800
Mitochondrial-targeting effector RsIA_CtaG/Cox11 in Rhizoctonia solani AG-1 IA has two functions: plant immunity suppression and cell death induction mediated by a rice cytochrome c oxidase subunit., PMID:37902589
Comprehensive analysis of copper-metabolism-related genes about prognosis and immune microenvironment in osteosarcoma., PMID:37700003
Identification of Copper Metabolism Related Biomarkers, Polygenic Prediction Model, and Potential Therapeutic Agents in Alzheimer's Disease., PMID:37694370
Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma., PMID:37405988
Expression and copper binding studies of a Plasmodium falciparum protein with Cox19 copper binding motifs., PMID:37348640
Copper metabolism in cell death and autophagy., PMID:37055935
Proteome profiles during early stage of somatic embryogenesis of two Eucalyptus species., PMID:36460945
Pan-cancer genetic analysis of cuproptosis and copper metabolism-related gene set., PMID:36276096
Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy., PMID:36030551
Germline allelic expression of genes at 17q22 locus associates with risk of breast cancer., PMID:35772352
Expression and copper binding characteristics of Plasmodium falciparum cytochrome c oxidase assembly factor 11, Cox11., PMID:35672733
A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase., PMID:35666203
The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis., PMID:34919594
The role of targeted regulation of COX11 by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia., PMID:34659807
RANBP2 mutation causing autosomal dominant acute necrotizing encephalopathy attenuates its interaction with COX11., PMID:34400285
Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources., PMID:33984024
Identification of a Candidate Gene for the Novel Cytoplasmic Male Sterility Derived from Inter-Subspecific Crosses in Rice (Oryza sativa L.)., PMID:33920582
Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure., PMID:31821401
Genome-Wide Homozygosity Patterns and Evidence for Selection in a Set of European and Near Eastern Horse Breeds., PMID:31261764
Crystal structure of WA352 provides insight into cytoplasmic male sterility in rice., PMID:29775612
Consequences of cytochrome c oxidase assembly defects for the yeast stationary phase., PMID:29567354
Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study., PMID:28757652
A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis., PMID:28082314
Multi-step formation, evolution, and functionalization of new cytoplasmic male sterility genes in the plant mitochondrial genomes., PMID:27725674
Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer., PMID:27516958
The Arabidopsis COX11 Homolog is Essential for Cytochrome c Oxidase Activity., PMID:26734017
Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase., PMID:25926683
Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration., PMID:25725288
Vascular endothelial growth factor recovers suppressed cytochrome c oxidase activity by restoring copper availability in hypertrophic cardiomyocytes., PMID:25107896
Genetic risk transmission in a family affected by familial breast cancer., PMID:24152768
Transcriptome changes favoring intramuscular fat deposition in the longissimus muscle following castration of bulls., PMID:23893995
Homocysteine restricts copper availability leading to suppression of cytochrome C oxidase activity in phenylephrine-treated cardiomyocytes., PMID:23818984
A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice., PMID:23502780
Association of STXBP4/COX11 rs6504950 (G>A) polymorphism with breast cancer risk: evidence from 17,960 cases and 22,713 controls., PMID:22863968
The role of genetic breast cancer susceptibility variants as prognostic factors., PMID:22532573
The roles of Rhodobacter sphaeroides copper chaperones PCu(A)C and Sco (PrrC) in the assembly of the copper centers of the aa(3)-type and the cbb(3)-type cytochrome c oxidases., PMID:22248670
Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men., PMID:21949660
Characterization of the peroxide sensitivity of COX-deficient yeast strains reveals unexpected relationships between COX assembly proteins., PMID:21821119
Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective., PMID:21816817
Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium., PMID:21791674
For research use only. Not for human or drug use.
