Catalog No.
YHB84001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly12-Pro429
Predicted molecular weight
48.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O96019
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BAF53, BAF53A, INO80K, BRG1-associated factor 53A, ArpNbeta, Actin-related protein Baf53a, INO80 complex subunit K, ACTL6A, Actin-like protein 6A, 53 kDa BRG1-associated factor A
Emerging Roles of ACTL6A as an Oncogenic Hub: Transcriptional Regulation and Beyond., PMID:40192597
Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma., PMID:40130245
Actl6a regulates autophagy via Sox2-dependent Atg5 and Atg7 expression to inhibit apoptosis in spinal cord injury., PMID:39875055
GG-NER's role in androgen receptor signaling inhibitor response for advanced prostate cancer., PMID:39696559
Circ_0084615 promotes epithelial-mesenchymal transition-mediated tumor progression in hepatocellular carcinoma., PMID:39502735
Structure of the human TIP60 complex., PMID:39154037
High expression of ACTL6A leads to poor prognosis of oral squamous cell carcinoma patients through promoting malignant progression., PMID:38523407
Gene amplification of chromatin remodeling factor SMARCC2 and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma., PMID:38516682
Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis., PMID:38464253
LOXL2-mediated chromatin compaction is required to maintain the oncogenic properties of triple-negative breast cancer cells., PMID:38451841
Discovery of a proliferation essential gene signature and actin-like 6A as potential biomarkers for predicting prognosis and neoadjuvant chemotherapy response in triple-positive breast cancer., PMID:38358781
TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma., PMID:38332153
Multiple independent de novo mutations are associated with the development of schistosoma reflexum, a lethal syndrome in cattle., PMID:38281659
Sulforaphane suppresses cell proliferation and induces apoptosis in glioma via the ACTL6A/PGK1 axis., PMID:38221767
Involvement of transcribed lncRNA uc.291 in hyperproliferative skin disorders., PMID:38041107
ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis., PMID:37443154
The theranostic value of acetylation gene signatures in obstructive sleep apnea derived by machine learning., PMID:37244148
Identification of mitophagy-related biomarkers and immune infiltration in major depressive disorder., PMID:37098514
Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas., PMID:36773604
Actin-like Protein 6A Expression Correlates with Cancer Stem Cell-like Features and Poor Prognosis in Ovarian Cancer., PMID:36768349
Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression., PMID:36631007
BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation., PMID:36526622
The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer., PMID:36430148
FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A., PMID:36159747
Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate., PMID:35817949
ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve., PMID:35434551
Involvement of transcribed lncRNA uc.291 and SWI/SNF complex in cutaneous squamous cell carcinoma., PMID:35201472
ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells., PMID:35182941
Retrospective analysis of a clinical exome sequencing cohort reveals the mutational spectrum and identifies candidate disease-associated loci for BAFopathies., PMID:34906496
DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription., PMID:34898277
ACTL6A suppresses p21Cip1 tumor suppressor expression to maintain an aggressive mesothelioma cancer cell phenotype., PMID:34689163
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma., PMID:34687603
Mechanism of Fuzheng Kang'ai Formula Regulating Tumor Microenvironment in Non-Small Cell Lung Cancer., PMID:34546538
Case Report: BAF-Opathies/SSRIDDs Due to a de novo ACTL6A Variant, Previously Considered to Be Heart-Hand Syndrome., PMID:34485408
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer., PMID:34395295
MicroRNA-543 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of triple-negative breast cancer cells via down-regulation of ACTL6A gene., PMID:34181232
ACTL6A promotes the growth in non-small cell lung cancer by regulating Hippo/Yap pathway., PMID:33896314
Clinicopathologic Characterization of Epithelioid Hemangioendothelioma in a Series of 62 Cases: A Proposal of Risk Stratification and Identification of a Synaptophysin-positive Aggressive Subset., PMID:33729740
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex., PMID:33602870
Actin-like protein 6A/MYC/CDK2 axis confers high proliferative activity in triple-negative breast cancer., PMID:33541412
ACTL6A Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells and Correlates with Poor Clinical Outcomes., PMID:33469301
ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer., PMID:33408251
Identification of a Twelve-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival for Medulloblastoma., PMID:33101383
Actin-like 6A enhances the proliferative and invasive capacities of laryngeal squamous cell carcinoma by potentiating the activation of YAP signaling., PMID:33067739
Persistence of Fear Memory Depends on a Delayed Elevation of BAF53b and FGF1 Expression in the Lateral Amygdala., PMID:32817243
ACTL6A suppresses p21Cip1 expression to enhance the epidermal squamous cell carcinoma phenotype., PMID:32616890
Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway., PMID:32514535
MiR-216a-3p suppresses the proliferation and invasion of cervical cancer through downregulation of ACTL6A-mediated YAP signaling., PMID:32401366
The Actin-Family Protein Arp4 Is a Novel Suppressor for the Formation and Functions of Nuclear F-Actin., PMID:32204557
Variant WWTR1 gene fusions in epithelioid hemangioendothelioma-A genetic subset associated with cardiac involvement., PMID:32170768
For research use only. Not for human or drug use.
