Catalog No.
YHA74701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser36-Gln348
Predicted molecular weight
37.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43681
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Arsenite-stimulated ATPase, TRC40, ATPase GET3, hASNA-I, Arsenical pump-driving ATPase, hARSA-I, GET3, ARSA, ASNA1, Guided entry of tail-anchored proteins factor 3, ATPase, Transmembrane domain recognition complex 40 kDa ATPase subunit
GET3B is involved in chloroplast biogenesis and interacts with the thylakoidal ALB3 and ALB4 insertases., PMID:40299103
Efficient gene transfer by pulse parameters for electrochemotherapy of cells in vitro and in muscle and melanoma tumors in mice., PMID:40256892
The formation of chaperone-rich GET bodies depends on the tetratricopeptide repeat region of Sgt2 and is reversed by NADH., PMID:39976550
FgGET3, an ATPase of the GET Pathway, Is Important for the Development and Virulence of Fusarium graminearum., PMID:39596240
Proteogenomic signature of risk of Alzheimer's disease and related dementia risk in individuals with a history of major depression disorder., PMID:39314945
A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo., PMID:38867239
Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad., PMID:38167697
The GET insertase exhibits conformational plasticity and induces membrane thinning., PMID:37963916
Proteome-wide abundance profiling of yeast deletion strains for GET pathway members using sample multiplexing., PMID:37882342
Intradimeric Walker A ATPases: Conserved Features of A Functionally Diverse Family., PMID:37330285
The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae., PMID:37286562
Structures of Get3d reveal a distinct architecture associated with the emergence of photosynthesis., PMID:37100288
The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER., PMID:36640319
Construction of noninvasive prognostic model of bladder cancer patients based on urine proteomics and screening of natural compounds., PMID:36562811
Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3., PMID:35851188
From guide to guard-activation mechanism of the stress-sensing chaperone Get3., PMID:35839781
Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway., PMID:35587358
CAMLG-CDG: a novel congenital disorder of glycosylation linked to defective membrane trafficking., PMID:35262690
Deciphering the molecular organization of GET pathway chaperones through native mass spectrometry., PMID:35189106
Structural insights into metazoan pretargeting GET complexes., PMID:34887561
A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum., PMID:34780541
Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion., PMID:34614151
A homolog of GuidedEntry of Tail-anchored proteins3 functions in membrane-specific protein targeting in chloroplasts of Arabidopsis., PMID:34021351
Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals., PMID:33838053
J-domain proteins promote client relay from Hsp70 during tail-anchored membrane protein targeting., PMID:33741343
Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast., PMID:33542241
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex., PMID:32910895
Searching for remote homologs of CAML among eukaryotes., PMID:32715580
Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins., PMID:31674906
Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy., PMID:31461301
The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER., PMID:31417168
The intracellular distribution of the components of the GET system in vascular plants., PMID:31233800
A trap mutant reveals the physiological client spectrum of TRC40., PMID:31182645
Characterization of Guided Entry of Tail-Anchored Proteins 3 Homologues in Mycobacterium tuberculosis., PMID:31036728
The natural history of Get3-like chaperones., PMID:30972921
Structural analysis of chloroplast tail-anchored membrane protein recognition by ArsA1., PMID:30891827
A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting., PMID:30605684
Substrate relay in an Hsp70-cochaperone cascade safeguards tail-anchored membrane protein targeting., PMID:29973361
Analysis of tail-anchored protein translocation pathway in plants., PMID:29872748
The ER membrane insertase Get1/2 is required for efficient mitophagy in yeast., PMID:29673596
The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER., PMID:29661846
Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins., PMID:29021347
A protean clamp guides membrane targeting of tail-anchored proteins., PMID:28973888
Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer., PMID:28877464
Mechanistic basis for a molecular triage reaction., PMID:28104892
Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance., PMID:28096354
Multiple selection filters ensure accurate tail-anchored membrane protein targeting., PMID:27925580
The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes., PMID:27923985
Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide., PMID:27736728
Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions., PMID:27765046
For research use only. Not for human or drug use.
