Catalog No.
YHK77001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser274-Ser358
Predicted molecular weight
21.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6ZN18
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Adipocyte enhancer-binding protein 2, Zinc finger protein AEBP2, AEBP2, AE-binding protein 2
Diverse RNA Structures Induce PRC2 Dimerization and Inhibit Histone Methyltransferase Activity., PMID:39257770
A preliminary study unveils CISD2 as a ferroptosis-related therapeutic target for recurrent spontaneous abortion through immunological analysis and two-sample mendelian randomization., PMID:38678819
Transcriptome-based network analysis of cell cycle-related genes in response to blue and red light in maize., PMID:38090389
Role of LncRNA MIR99AHG in breast cancer: Bioinformatic analysis and preliminary verification., PMID:37809464
H2A Ubiquitination Alters H3-tail Dynamics on Linker-DNA to Enhance H3K27 Methylation., PMID:36610636
The Role of Polycomb Proteins in Cell Lineage Commitment and Embryonic Development., PMID:35997369
Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos., PMID:34982026
Joint single-cell multiomic analysis in Wnt3a induced asymmetric stem cell division., PMID:34642323
AC092127.1-miR-451a-AE binding protein 2 Signaling Facilitates Malignant Properties of Breast Cancer., PMID:34352938
Cooperative DNA looping by PRC2 complexes., PMID:34057467
SUMO pathway, blood coagulation and oxidative stress in SARS-CoV-2 infection., PMID:33558851
Polycomb repressor complex 2 function in breast cancer (Review)., PMID:33491744
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications., PMID:33479123
Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid., PMID:32043141
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin., PMID:31959557
β-TRCP-mediated AEBP2 ubiquitination and destruction controls cisplatin resistance in ovarian cancer., PMID:31864706
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation., PMID:31521505
Polycomb repressive 2 complex-Molecular mechanisms of function., PMID:31095801
Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding., PMID:30451485
A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma., PMID:29960071
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits., PMID:29891558
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2., PMID:29681498
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities., PMID:29628311
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding., PMID:29499137
JARID2 and AEBP2 Mimic Histone Tails to Promote PRC2 Activity., PMID:29420179
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes., PMID:29379173
Structures of human PRC2 with its cofactors AEBP2 and JARID2., PMID:29348366
Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4., PMID:29134516
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA., PMID:29058709
Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs., PMID:27317809
The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes., PMID:27022003
Retrotransposon-derived promoter of Mammalian Aebp2., PMID:25915901
AEBP2 as a transcriptional activator and its role in cell migration., PMID:25451679
Role of PRC2-associated factors in stem cells and disease., PMID:25271128
Profiling of embryonic stem cell differentiation., PMID:25148369
Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression., PMID:24837194
Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification., PMID:24550272
Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3., PMID:23744963
Molecular architecture of human polycomb repressive complex 2., PMID:23110252
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies., PMID:22190018
Aebp2 as an epigenetic regulator for neural crest cells., PMID:21949878
An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells., PMID:21362171
Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions., PMID:20167128
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2., PMID:19293275
Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning., PMID:17321057
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex., PMID:15225548
The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea., PMID:12015288
Jing: a downstream target of slbo required for developmental control of border cell migration., PMID:11152631
Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression., PMID:10329662
For research use only. Not for human or drug use.
