Catalog No.
YHG12901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys111-Gly276
Predicted molecular weight
21.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07666
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p21 Ras GTPase-activating protein-associated p62, GAP-associated tyrosine phosphoprotein p62, KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, p68, Sam68, KHDRBS1, Src-associated in mitosis 68 kDa protein
Khdrbs1 drives re-differentiation of bipotential progenitor cells by inhibiting p53 in zebrafish biliary-mediated liver regeneration., PMID:39963927
Effects of the RNA-Binding Protein Sam68 on Poly(ADP-Ribose)polymerase 1 Activity., PMID:39865028
KHDRBS1 regulates the pentose phosphate pathway and malignancy of GBM through SNORD51-mediated polyadenylation of ZBED6 pre-mRNA., PMID:39516455
Role of Sam68 in different types of cancer (Review)., PMID:39450529
Integration of bioinformatics and multi-layered experimental validation reveals novel functions of acetylation-related genes in intervertebral disc degeneration., PMID:39349110
KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity., PMID:38660302
Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development., PMID:38324473
Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis of associative gene networks help., PMID:38213696
Sam68 is a druggable vulnerability point in cancer stem cells., PMID:37792222
CircMTA1 promotes glioblastoma angiogenesis by encoding MTA1-134aa., PMID:37750502
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer., PMID:37208334
Role of CCT4/ErbB signaling in nephroblastoma: Implications for a biomarker of Wilms tumor., PMID:37058032
A positive feedback circuit between RN7SK snRNA and m6A readers is essential for tumorigenesis., PMID:36566349
Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts., PMID:36560896
Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions., PMID:36537190
The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer., PMID:36344846
Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect-based chemical-enrichment method., PMID:36256816
Shortening of the KHDRBS1 3'UTR by alternative cleavage and polyadenylation alters miRNA-mediated regulation and promotes gastric cancer progression., PMID:36247240
Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity., PMID:36232770
Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients., PMID:36139396
High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma., PMID:36082807
Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51., PMID:35217791
Genetics of ovarian insufficiency and defects of folliculogenesis., PMID:34794894
Sam68 contributes to intestinal inflammation in experimental and human colitis., PMID:34693458
miR-200b-3p alleviates TNF-α-induced apoptosis and inflammation of intestinal epithelial cells and ulcerative colitis progression in rats via negatively regulating KHDRBS1., PMID:34629748
Splicing machinery is impaired in rheumatoid arthritis, associated with disease activity and modulated by anti-TNF therapy., PMID:34625402
Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines., PMID:34495685
Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects., PMID:34260915
Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure., PMID:34252225
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified., PMID:34140493
Sam68 promotes hepatic gluconeogenesis via CRTC2., PMID:34099657
Unclassified mesenchymal sarcoma with NTRK1-KHDRBS1 gene fusion: a case report of long-term tumor-free survival with crizotinib treatment., PMID:33941195
A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation., PMID:33656539
SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing., PMID:33537092
Cold-induced RNA-binding protein (CIRBP) regulates the expression of Src-associated during mitosis of 68 kDa (Sam68) and extracellular signal-regulated kinases (ERK) during heat stress-induced testicular injury., PMID:33308394
Intronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing., PMID:33292386
Leptin, Leptin Receptor, KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1), and Adiponectin in Bone Metastasis from Breast Carcinoma: An Immunohistochemical Study., PMID:33213024
Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency., PMID:33068876
ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs., PMID:32780150
Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscle., PMID:32753528
Antibody-based biosensor to detect oncogenic splicing factor Sam68 for the diagnosis of lung cancer., PMID:32648188
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum., PMID:32492419
Stimulated emission depletion (STED) super resolution imaging of RNA- and protein-containing domains in fixed cells., PMID:32360441
KMT Set7/9 is a new regulator of Sam68 STAR-protein., PMID:32178870
The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis., PMID:31863590
Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization., PMID:31777926
Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons., PMID:31722197
Sam68 impedes the recovery of arterial injury by augmenting inflammatory response., PMID:31639388
Sam68 mediates high glucose‑induced podocyte apoptosis through modulation of Bax/Bcl‑2., PMID:31485651
Sam68 is required for the growth and survival of nonmelanoma skin cancer., PMID:31436046
For research use only. Not for human or drug use.
