Catalog No.
YHE88001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp64-Arg383
Predicted molecular weight
39.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51812
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Insulin-stimulated protein kinase 1, MAP kinase-activated protein kinase 1b, ISPK-1, RSK2, Ribosomal S6 kinase 2, MAPKAPK-1b, ISPK1, pp90RSK2, p90RSK3, RSK-2, 90 kDa ribosomal protein S6 kinase 3, MAPKAPK1B, S6K-alpha-3, MAPKAP kinase 1b, p90-RSK 3, RPS6KA3, MAPK-activated protein kinase 1b, Ribosomal protein S6 kinase alpha-3
Bisphenol a Disrupts Steroidogenesis and Induces Apoptosis in Human Granulosa Cells Cultured In Vitro., PMID:40362320
RSK2 and its binding partners: an emerging signaling node in cancers., PMID:40320503
The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton., PMID:40140815
RSK2-mediated phosphorylation and degradation of UBE2O inhibits hepatocellular carcinoma growth and resistance to radiotherapy., PMID:39954933
The Clinical and Molecular Spectrum of Patients With X-Linked Intellectual Disability and Novel Variations in Different Genes., PMID:39951932
Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model., PMID:39883715
Polyphenol Profile and Antioxidant, Antityrosinase, and Anti-Melanogenesis Activities of Ethanol Extract of Bee Pollen., PMID:39770476
Effectiveness and Impact of Transcript Analysis in Clinical Genetics Daily Practice., PMID:39707869
RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data., PMID:39632509
Diosmin alleviates NLRP3 inflammasome-dependent cellular pyroptosis after stroke through RSK2/CREB pathway., PMID:39547499
Stimulation of insulin secretion induced by low 4-cresol dose involves the RPS6KA3 signalling pathway., PMID:39446839
Robust anti-myeloma effect of TAS0612, an RSK/AKT/S6K inhibitor, with venetoclax regardless of cytogenetic abnormalities., PMID:39438587
Targeting RSK2 in Cancer Therapy: A Review of Natural Products., PMID:39248063
Novel gene fusions in human oropharyngeal carcinoma., PMID:38971117
Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis., PMID:38658799
Exploring the therapeutic mechanism of potential phytocompounds from Kalanchoe pinnata in the treatment of diabetes mellitus by integrating network pharmacology, molecular docking and simulation approach., PMID:38550331
Ribosomal protein S6 kinase 2 (RPS6KB2) is a potential immunotherapeutic target for cancer that upregulates proinflammatory cytokines., PMID:38281249
RSK3 switches cell fate: from stress-induced senescence to malignant progression., PMID:38008756
Impact of Genomic Alterations on the Clinical Outcome of Patients With Hepatitis B-related Hepatocellular Carcinoma Receiving Curative Surgery: A Retrospective Cohort Study., PMID:37772577
A 6-year-old boy with an atypical liver neoplasm harboring a novel RPS6KA3 variant., PMID:37477894
A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction., PMID:37285335
Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function., PMID:37240151
RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis., PMID:37201672
The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling., PMID:37149146
mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer., PMID:36883564
A novel ribosomal protein S6 kinase 2 inhibitor attenuates the malignant phenotype of cutaneous malignant melanoma cells by inducing cell cycle arrest and apoptosis., PMID:36700473
EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer., PMID:36516759
Identification of Potential miRNA-mRNA Regulatory Network Associated with Pig Growth Performance in the Pituitaries of Bama Minipigs and Landrace Pigs., PMID:36359184
An unusual familial Xp22.12 microduplication including EIF1AX: A novel candidate dosage-sensitive gene for premature ovarian insufficiency., PMID:36113757
CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway., PMID:35964097
Coffin-Lowry Syndrome Induced by RPS6KA3 Gene Variation in China: A Case Report in Twins., PMID:35888677
ERK1/2-RSK2 Signaling in Regulation of ERα-Mediated Responses., PMID:35880639
P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment., PMID:35875157
Ribosomal S6 Protein Kinase 2 Aggravates the Process of Systemic Scleroderma., PMID:35853487
Short Bones, Renal Stones, and Diagnostic Moans: Hypercalcemia in a Girl Found to Have Coffin-Lowry Syndrome., PMID:35638718
Cold atmospheric plasmas target breast cancer stemness via modulating AQP3-19Y mediated AQP3-5K and FOXO1 K48-ubiquitination., PMID:35637961
ERK1/2-RSK regulation of oestrogen homeostasis., PMID:35176205
Association Between RSK2 and Clinical Indexes of Primary Breast Cancer: A Meta-Analysis Based on mRNA Microarray Data., PMID:34790230
Consensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers., PMID:34743649
Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer., PMID:34550011
Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling., PMID:34504181
Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia., PMID:34373588
Identifying requirements for RSK2 specific inhibitors., PMID:34348556
N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors., PMID:34034149
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1., PMID:33709453
Role of UTX Histone Demethylase in Regulation of MGMT, TRA2A, U2AF1, and RPS6KA2 Genes in Prostate Cancer Cell Lines., PMID:33337267
Evaluation of imidazo[2,1-b]thiazole-based anticancer agents in one decade (2011-2020): Current status and future prospects., PMID:33316752
Feasibility of phosphoproteomics to uncover oncogenic signalling in secreted extracellular vesicles using glioblastoma-EGFRVIII cells as a model., PMID:33307249
Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level., PMID:33296655
For research use only. Not for human or drug use.
