Catalog No.
YHG84801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly32-Gly267
Predicted molecular weight
28.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14624
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Inter-alpha-trypsin inhibitor family heavy chain-related protein, Inter-alpha-trypsin inhibitor heavy chain H4, PK120, PK-120, Plasma kallikrein sensitive glycoprotein 120, Inter-alpha-inhibitor heavy chain 4, ITIHL1, ITIH4, IHRP, ITI-HC4, ITI heavy chain H4, Gp120
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells., PMID:40437524
ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota., PMID:40410722
Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of chronic obstructive pulmonary disease through JNK-dependent and JNK-independent signaling., PMID:40404214
Vibrio mimicus digests intestinal peritrophin-44 and disrupts hemolymph bacterial balance in crustaceans., PMID:40383494
Identifying novel protein biomarkers with cross-psychiatric disorders effects and potential intervention targets: Evidence from proteomic-Mendelian randomization., PMID:40334965
Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis., PMID:40214957
Identification of noval diagnostic biomarker for HFpEF based on proteomics and machine learning., PMID:40200297
Mendelian randomization analysis of the causal relationship between plasma proteins and childhood asthma., PMID:40193678
Lentiviral Injection of Inter-α-Trypsin Inhibitor Heavy Chain 4 Promotes Female Spinal Cord Injury Mice Recuperation by Diminishing Peripheral and Central Inflammation., PMID:39648260
Dynamics of the blood plasma proteome during hyperacute HIV-1 infection., PMID:39632834
Identifying therapeutic targets for kidney stone disease through proteome-wide Mendelian randomization and colocalization analysis., PMID:39585470
Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors., PMID:39500886
Serum proteomic analysis identified ITIH4 as a potential novel biomarker for feline infectious peritonitis., PMID:39454824
Plasma alpha-trypsin inhibitor heavy chain 4 as an age-specific biomarker in the diagnosis and treatment of major depressive disorder., PMID:39323962
ITIH4 in Rheumatoid Arthritis Pathogenesis: Network Pharmacology and Molecular Docking Analysis Identify CXCR4 as a Potential Receptor., PMID:39311312
ITIH4 reversed the effects of thrombin on VSMCs stiffness via JNK and ERK signaling pathway., PMID:39069151
Blood Plasma Markers in Depressed Mice under Chronic Social Defeat Stress., PMID:39062058
ITIH4 is a predictor for coronary thrombus in coronary arteriography patients., PMID:39041488
Discovery, identification and mechanism of chemosensitivity-relate biomarker inter-α-trypsin inhibitor heavy chain 4 in metastatic colorectal cancer., PMID:39040328
Linkage of serum ITIH4 with Th2 signature cytokine, inflammation, exacerbation risk and severity in childhood asthma., PMID:39011671
Conjugated linoleic acid (CLA) modulates bovine peripheral blood mononuclear cells (PBMC) proteome in vitro., PMID:38909954
Serum proteomic analysis uncovers novel serum biomarkers for depression., PMID:38895030
Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) as a compensatory protease inhibitor in hereditary angioedema., PMID:38657796
Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis., PMID:38585359
Research Trends in Proteomic Studies Using Serum from COVID-19 Patients: A Bibliometric Analysis., PMID:38584539
Large-Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis., PMID:38380496
Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis., PMID:38289873
Idiopathic pulmonary fibrosis-specific Bayesian network integrating extracellular vesicle proteome and clinical information., PMID:38225283
Identification of an inflammation-related risk signature for prognosis and immunotherapeutic response prediction in bladder cancer., PMID:38216619
Role of inter-alpha-trypsin inhibitor heavy chain 4 and its citrullinated form in experimental arthritis murine models., PMID:38190323
Serum interα-trypsin inhibitor heavy chain H4 may be an anti-inflammatory marker reflecting disease risk, activity and treatment outcome of ankylosing spondylitis., PMID:38156824
Mendelian randomization reveals plasminogen as a common therapeutic target for myocardial infarction and atrial fibrillation., PMID:40027362
Relationships between haptoglobin and inter-alpha trypsin inhibitor heavy chain 4 levels in local and peripheral blood and systemic inflammatory response syndrome in bitches with pyometra., PMID:38090953
Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethral stricture disease., PMID:38032942
LC-MS/MS Quantitation of HILIC-Enriched N-glycopeptides Derived from Low-Abundance Serum Glycoproteins in Patients with Narcolepsy Type 1., PMID:38002271
A Prospective Cohort Study of Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 as a Serologic Marker in Relation to Severity and Functional Outcome of Acute Intracerebral Hemorrhage., PMID:37954033
Gaining knowledge about biomarkers of the immune system and inflammation in the saliva of pigs: The case of myeloperoxidase, S100A12, and ITIH4., PMID:37657394
Changes in S100A8/A9 and S100A12 and Their Comparison with Other Analytes in the Saliva of Pigs with Diarrhea Due to E. coli., PMID:37627347
Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics., PMID:37621164
Changes in salivary biomarkers of stress, inflammation, redox status, and muscle damage due to Streptococcus suis infection in pigs., PMID:37525237
Network proteomic analysis identifies inter-alpha-trypsin inhibitor heavy chain 4 during early human Achilles tendon healing as a prognostic biomarker of good long-term outcomes., PMID:37483617
Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique and May Contribute to CRF01_AE Transmission Among Men Who Have Sex with Men in China and Thailand., PMID:37335061
LC-MS/MS-Based Proteomics Approach for the Identification of Candidate Serum Biomarkers in Patients with Narcolepsy Type 1., PMID:36979356
Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events., PMID:36891881
Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation., PMID:36876284
PGK1 modulates balance between pro- and anti-inflammatory cytokines by interacting with ITI-H4., PMID:36841032
Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis., PMID:36725250
Longitudinal Change of Serum Inter-α-Trypsin Inhibitor Heavy Chain H4 and its Relation with Inflammation, Disease Recurrence, and Mortality in Acute Ischemic Stroke Patients., PMID:36596502
Acute phase proteins in cattle and swine: A review., PMID:36526287
Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock., PMID:36459524
For research use only. Not for human or drug use.
